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GRIP1 Antibodies
AND GRIP1 ELISA kits, GRIP1 Proteins
Many biological assays use antibodies to detect GRIP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRIP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRIP1 antibodies...
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GRIP1 Overview
Facts about Glutamate receptor-interacting protein 1.
Glutamate receptor-interacting protein 1 (GRIP1)
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of this GRIA2 subunit toward recycling and membrane targeting (By similarity).
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Gene Information
| Human | |
|---|---|
| Gene Name: | GRIP1 |
| Uniprot: | Q9Y3R0 |
| Entrez: | 23426 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
glutamate receptor interacting protein 1; glutamate receptor-interacting protein 1; GRIP; GRIP-1
Molecular Weight
Mass (kDA):
122.422 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q14.3 |
| Sequence: | 12; NC_000012.12 (66347431..67069265, complement) |
Subcellular Localizations
Cytoplasmic vesicle. Perikaryon. Cell projection, dendrite. Cytoplasm. Endomembrane system; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic density. Endoplasmic reticulum membrane; Peripheral membrane protein. Membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in postsynaptic plasma membrane and postsynaptic densities.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Depressive Disorder
- Neoplasms
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
- Bulla
- Tissue Adhesions
- Carcinoma
- Cryptophthalmos Syndrome
- Liver Carcinoma
- Schizophrenia
Interacting Proteins
- ESR1
- IRF3
- PRLHR
- PSMB9
Pathways
- Localization
- Synaptic Transmission
- Methylation
- Endocytosis
- Cell Proliferation
- Transport
- Chromatin Remodeling
- Cell Growth
- Receptor Recycling
- Receptor Clustering
- Receptor Internalization
- Pathogenesis
- Hyperphosphorylation
PTMs
- Phosphorylation
- Methylation
- Acetylation
- Reduction
- Palmitoylation
- Ubiquitination
Research Areas
- Cancer
- Neuronal Cell Markers
- Neurotransmission
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRIP1
bosterbio.com/bosterbio-gene-info-cards/GRIP1
References
PMID: 10197531 by Brueckner K., et al. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains.
PMID: 11641419 by Lin S.H.S., et al. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy- 5-methylisoxazole-4-propionic acid receptor clustering.