GRIN2D Antibodies

AND GRIN2D ELISA kits, GRIN2D Proteins

Many biological assays use antibodies to detect GRIN2D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRIN2D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRIN2D antibodies...

We validate the specificity of these antibodies to GRIN2D by testing them on tissues known to express GRIN2D positively and negatively. Browse below to find the GRIN2D antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GRIN2D Infographic by Boster Bio

All GRIN2D Products

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Product

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Specificity

Applications

Price

Anti-NMDA epsilon4 GRIN2D Antibody

Human, Monkey, Mouse, Rat

$399
Cat # A08091
100μl

Anti-GRIN2D/Nmdar2D Antibody

1 Citations 5 Q&As

Human, Monkey, Mouse, Rat

ELISA, WB

$335
Cat # A30704
100ul

GRIN2D Overview

Facts about Glutamate receptor ionotropic, NMDA 2D.

GRIN2D 3D structure. Source: alphafold

Glutamate receptor ionotropic, NMDA 2D (GRIN2D)

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851).

Sensitivity to glutamate and channel kinetics are determined by the subunit composition (PubMed:9489750). .

Gene Information

Human
Gene Name:	GRIN2D
Uniprot:	O15399
Entrez:	2906

Family

Belongs to:

glutamate-gated ion channel (TC 1.A.10.1) family

Alternative Names

EB11estrogen receptor binding CpG island; glutamate receptor, ionotropic, N-methyl D-aspartate 2D; NMDA epsilon 4; NMDAR2DN-methyl-d-aspartate receptor subunit 2D; N-methyl D-aspartate receptor subtype 2D; NR2Dglutamate [NMDA] receptor subunit epsilon-4

Molecular Weight

Mass (kDA):
143.752 kDA

Genomic Context


Human

Location:	19q13.33
Sequence:	19; NC_000019.10 (48394875..48444937)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Diseases

Schizophrenia
Psychotic Disorders
Pcp - Hallucinogen-related Disorder
Malignant Neoplasm Of Breast
Idiopathic Pneumonia Syndrome
De Novo Mutation
Lordosis
Pregnancy Complications, Infectious
Cancer Patients And Suicide And Depression
Epilepsy

Generalized Seizures
Autistic Disorder
Malignant Neoplasms
Impaired Cognition
Mammary Neoplasms

Interacting Proteins

Dlg3

Pathways

Brain Development
Localization
Pathogenesis
Reproductive Behavior

PTMs

Disulfide bond
Glycoprotein

Methylation
Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRIN2D

References

PMID: 9489750 by Hess S.D., et al. Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.

PMID: 27616483 by Li D., et al. GRIN2D recurrent de novo dominant mutation causes a severe epileptic encephalopathy treatable with NMDA receptor channel blockers.

1 Publications of Boster GRIN2D Antibodies & ELISA Kits

PubMed ID: 10.1016/j.tiv.2017.10.008, The excitotoxity of NMDA receptor NR2D subtype mediates human fetal lung fibrobl...

*More publications can be found for each product on its corresponding product page