GRID2 Antibodies

Glutamate receptor ionotropic, delta-2 (GRID2)

Receptor for glutamate.

L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine- dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex (PubMed:27418511).

Gene Information

Human
Gene Name:	GRID2
Uniprot:	O43424
Entrez:	2895

Family

Belongs to:
glutamate-gated ion channel (TC 1.A.10.1) family

Alternative Names

B230104L07Rik; cpr; creeper; gluR delta-2 subunit; GLURD2; GluRdelta2; glutamate receptor delta-2 subunit; glutamate receptor, ionotropic, delta 2; GRID2; ho; hotfoot; Lc; lurcher; minisatellite 10ac detected by probe MMS10; MMS10-AC; Ms10ac; nmf408; SCAR18; tpr

Molecular Weight

Mass (kDA):
113.356 kDA

Genomic Context

Human
Location:	4q22.1-q22.2
Sequence:	4; NC_000004.12 (92303622..93810415)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Diseases

• Ataxia
• Nerve Degeneration
• Malignant Neoplasms
• Neoplasms
• Atrophy
• Cytopathic Effect
• Cerebellar Ataxia
• Genomic Instability
• Depressive Disorder
• Cerebellar Diseases
• Endometrial Polyp

• Endometrial Carcinoma
• Movement Disorders
• Varicosity
• Malignant Neoplasm Of Brain
• Sensation Disorders
• Carcinoma

Pathways

• Cell Death
• Autophagy
• Bioluminescence
• Transport
• Prepulse Inhibition
• Dendrite Development
• Synaptic Transmission
• Endocytosis
• Oxidative Phosphorylation

• Nerve Development
• Mitochondrial Fission
• Cell Growth
• Innervation

PTMs

• Phosphorylation

Research Areas

• Neuronal Cell Markers
• Neurotransmission

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRID2

Best Uses Of The GRID2 Marker

If you're considering purchasing an antibody for the GRID2 marker, read on for more information. Boster Bio's antibodies are trusted by researchers and are available in several formats, including WB and picoband. Read on to learn how to use this powerful marker to your advantage. Here are the best uses for the GRID2 marker. Listed below are some of the most popular uses.

Boster's antibodies are validated on WB

Boster Bio has a diverse product line of over 12,000 antibodies that have been extensively validated on WB and IHC. Boster also offers rabbit polyclonal antibodies, a free secondary antibody with the purchase of a primary antibody, and a selection of ELISA kits. All Boster Bio antibodies are designed for optimum performance, with high affinity and selectivity against known recombinant proteins and untransfected cell lines.

Immunoblotting is not a perfect assay, and antibodies cannot be tested on denatured or truncated proteins. But if you do not know the sensitivity and specificity of a particular antibody, WB is a good way to test it. In addition to IHC and ICC, WB also allows you to compare antibody-dilutions and determine whether an antibody has good specificity or not.

Western blot is widely used to assess the specificity of an antibody. If an antibody is known to recognize a denatured antigen, a single band at a known molecular weight will indicate that the antibody is specific. However, if multiple bands are detected, these may represent different targets with different post-translational modifications, splice variants, and other factors. This should raise concern and prompt further experiments.

After determining the specificity of an antibody, the corresponding mAb must match the target protein by producing similar staining patterns. This method requires a thorough knowledge of the target protein's sequence. It is possible to apply this method to WB and ICC-IF data to validate an antibody. When these steps are carried out, you'll have an antibody that matches a high-quality target protein and is highly specific.

In addition to WB and IHC validation, antibodies for Boster's immunohistochemistry products should be tested on various types of target cells. In particular, antigens containing phosphorylated residues should be tested for fidelity and specificity in order to ensure accuracy. The validation of a WB antibody is especially important for IHC and WB, and antibodies that are validated on this assay are guaranteed to have excellent specificity.

Boster's antibodies are available in picoband

Boster Bio is a biotech company that offers an exclusive range of antibodies known as Picoband. Each of these antibodies is highly sensitive and designed to have the lowest cross-reactivity and highest affinity. The result is stunning immunohistochemistry and Western Blot images. The Picoband range is available in several formats and includes a wide selection of proteins. Here are the benefits of using Picoband antibodies.

Boster Bio's Anti-ADO Antibody Picoband is a Rabbit Polyclonal antibody that has been shown to work in Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Flow Cytometry. This antibody was developed using ADO as its antigen and has been validated for use in human and mouse samples. For this specific antibody, boster has also validated antibodies against other species.

Boster's antibodies are available in a variety of formats

There are a number of advantages to using Boster's antibodies. The primary and secondary labeling systems help researchers ask more questions about the specimens. These systems also include more contextual data to support the results. The authors of the book list the benefits of these systems. To learn more, contact the authors. Boster's antibodies are available in several formats, including whole blood, serum, and serum-free liquid.