GRHL2 Antibodies

AND GRHL2 ELISA kits, GRHL2 Proteins

Many biological assays use antibodies to detect GRHL2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRHL2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRHL2 antibodies...

We validate the specificity of these antibodies to GRHL2 by testing them on tissues known to express GRHL2 positively and negatively. Browse below to find the GRHL2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GRHL2 Infographic by Boster Bio

All GRHL2 Products

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Product

Figures

Specificity

Applications

Price

Anti-GRHL2 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A04120-2
100 μg/vial

GRHL2 (NM_024915) Human Over-expression Lysate

Human

$960
Cat # LS079977
100 µg

GRHL2 Overview

Facts about Grainyhead-like protein 2 homolog.

GRHL2 3D structure. Source: alphafold

Grainyhead-like protein 2 homolog (GRHL2)

Transcription factor playing an essential role in primary neurulation and in epithelial development (PubMed:29309642, PubMed:25152456). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity).

During embryogenesis, plays with unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closing 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closed 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity).

Gene Information

Human
Gene Name:	GRHL2
Uniprot:	Q6ISB3
Entrez:	79977

Family

Belongs to:

grh/CP2 family

Alternative Names

BOMMGC149294; Brother of mammalian grainyhead; deafness, autosomal dominant 28; DFNA28; FLJ13782; grainyhead-like 2 (Drosophila); grainyhead-like protein 2 homolog; TFCP2L3MGC149295; Transcription factor CP2-like 3FLJ11172

Molecular Weight

Mass (kDA):
71.105 kDA

Genomic Context


Human

Location:	8q22.3
Sequence:	8; NC_000008.11 (101492439..101678104)

Tissue Specificity

Expressed in keratinocytes (at protein level). Highly expressed in placenta, prostate, brain and kidney. Lower- level expression in a variety of epithelial tissues such as thymus, lung, salivary gland, mammary gland and digestive tract. Expressed in the cochlear.

Subcellular Localizations

Nucleus. Membrane. detected at cell-cell contact areas.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Congenital Abnormality
Tissue Adhesions
Neoplasm Metastasis
Carcinoma
Mammary Neoplasms
Presbycusis
Stenosis
Diabetic Nephropathy
Tumor Progression

Dermatitis, Atopic
Disseminated Malignant Neoplasm
Diabetic Neuropathies
Coronary Artery Disease
Malignant Neoplasm Of Lung
Deregulation Of Apoptosis
Carcinogenesis

Interacting Proteins

LMO4

Pathways

Neural Tube Closure
Tube Closure
Cell Proliferation
Cell Migration
Wound Healing
Cell Morphogenesis
Localization
Transport
Cell Adhesion
Organic Acid Transport
Dorsal Closure
Tube Fusion
Keratinocyte Differentiation

Embryo Development
Swimming
Cell Cycle
Cell Morphogenesis Involved In Differentiation
Placenta Development
Epithelial Cell Morphogenesis
Cell-cell Adhesion

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRHL2

References

PMID: 12393799 by Peters L.M., et al. Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28.

PMID: 12175488 by Wilanowski T., et al. A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead.