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GPRC5B Antibodies
AND GPRC5B ELISA kits, GPRC5B Proteins
Many biological assays use antibodies to detect GPRC5B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GPRC5B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GPRC5B antibodies...
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GPRC5B Overview
Facts about G-protein coupled receptor family C group 5 member B.
G-protein coupled receptor family C group 5 member B (GPRC5B)
Unknown.
This retinoic acid-inducible G-protein coupled receptor provide evidence for a potential interaction between retinoid and G-protein signaling pathways..
Gene Information
| Human | |
|---|---|
| Gene Name: | GPRC5B |
| Uniprot: | Q9NZH0 |
| Entrez: | 51704 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 3 family |
Alternative Names
G protein-coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 5, member B; GPRC5B; RAIG2; RAIG-2A-69G12.1; RAIG2G-protein coupled receptor family C group 5 member B; retinoic acid responsive gene protein; Retinoic acid-induced gene 2 protein
Molecular Weight
Mass (kDA):
44.795 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p12.3 |
| Sequence: | 16; NC_000016.10 (19856691..19886045, complement) |
Tissue Specificity
Expression is high in kidney, pancreas, and testis, medium in brain, heart, prostate, small intestine, and spleen, low in liver, placenta, skeletal muscle, colon, ovary, and thymus, and not detectable in lung and peripheral leukocyte. According to PubMed:10945465, highly expressed in most brain areas examined, with the highest levels observed in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus, and spinal chord as well as in dorsal root ganglia (DRG). In the periphery, expression levels are relatively low, compared to the CNS, with the strongest expression detected in pancreas, testis, uterus, and stomach.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Localized in the plasma membrane and perinuclear vesicles.
Diseases
- Nervousness
- Obesity
- Neuroblastoma
- Brain Ischemia
- Occlusion, Middle Cerebral Artery
- Arterial Occlusion
- Diabetes Mellitus
- Insulin Resistance
- Diabetes Mellitus, Non-insulin-dependent
- Tumor Angiogenesis
- Neoplasms
Pathways
- Keratinization
- Catagen
- Cell Proliferation
- Regulation Of Secretion
- Localization
- Regeneration
- Tissue Regeneration
- Cell Motility
- Cell Death
PTMs
Research Areas
- GPCR
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPRC5B
bosterbio.com/bosterbio-gene-info-cards/GPRC5B
References
PMID: 10783259 by Braeuner-Osborne H., et al. Sequence and expression pattern of a novel human orphan G-protein- coupled receptor, GPRC5B, a family C receptor with a short amino- terminal domain.
PMID: 10945465 by Robbins M.J., et al. Molecular cloning and characterization of two novel retinoic acid- inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C).