GPR75 Antibodies

AND GPR75 ELISA kits, GPR75 Proteins

Many biological assays use antibodies to detect GPR75, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GPR75 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GPR75 antibodies...

We validate the specificity of these antibodies to GPR75 by testing them on tissues known to express GPR75 positively and negatively. Browse below to find the GPR75 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GPR75 Infographic by Boster Bio

All GPR75 Products

Product

Figures

Specificity

Applications

Price

Anti-GPR75 Antibody

4 Q&As

Human, Mouse

ELISA, IF, WB

$399
Cat # A13384
100μl

Anti-GPR75 Antibody

Human, Mouse, Rat

ICC, WB

$405
Cat # A13384-1
100ul

GPR75 (NM_006794) Human Over-expression Lysate

Human

$628
Cat # LS010936
100 µg

GPR75 Overview

Facts about Probable G-protein coupled receptor 75.

GPR75 3D structure. Source: alphafold

Probable G-protein coupled receptor 75 (GPR75)

G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation.

Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway between the PI3, Akt and MAP kinases. CCL5/RANTES can also modulate insulin secretion by pancreatic islet cells through activation of this receptor.

Gene Information

Human
Gene Name:	GPR75
Uniprot:	O95800
Entrez:	10936

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

G protein-coupled receptor 75; GPR75; GPRchr2; MGC132002; probable G-protein coupled receptor 75; WI31133; WI-31133

Molecular Weight

Mass (kDA):
59.359 kDA

Genomic Context


Human

Location:	2p16.2
Sequence:	2; NC_000002.12 (53852912..53859967, complement)

Tissue Specificity

Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level).

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Alzheimer's Disease
Retinal Dystrophies
Age Related Macular Degeneration
Retinal Degeneration
Neoplasms
Mammary Neoplasms
Pertussis
Neurotoxicity Syndromes

Retinal Diseases
Dystrophy

Pathways

Bioluminescence
Pathogenesis

PTMs

Phosphorylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPR75

References

PMID: 10381362 by Tarttelin E.E., et al. Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16.

PMID: 23979485 by Liu B., et al. The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis.