GPR39 Antibodies

AND GPR39 ELISA kits, GPR39 Proteins

Many biological assays use antibodies to detect GPR39, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GPR39 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GPR39 antibodies...

We validate the specificity of these antibodies to GPR39 by testing them on tissues known to express GPR39 positively and negatively. Browse below to find the GPR39 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GPR39 Infographic by Boster Bio

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Anti-G-protein coupled receptor 39 GPR39 Antibody

Human

ELISA, WB

$380
Cat # A04330
100ul

GPR39 Overview

Facts about G-protein coupled receptor 39.

GPR39 3D structure. Source: alphafold

G-protein coupled receptor 39 (GPR39)

Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).

Gene Information

Human
Gene Name:	GPR39
Uniprot:	O43194
Entrez:	2863

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

G protein-coupled receptor 39; GPR39; G-protein coupled receptor 39; MGC149541

Molecular Weight

Mass (kDA):
51.329 kDA

Genomic Context


Human

Location:	2q21.2
Sequence:	2; NC_000002.12 (132416805..132646582)

Tissue Specificity

Expressed in many tissues, including the stomach, intestine and hypothalamus.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Pituitary Diseases
Diabetes Mellitus
Obesity
Malignant Neoplasms
Nervousness
Diabetes Mellitus, Non-insulin-dependent
Neoplasms
Impaired Glucose Tolerance
Anxiety Disorders
Hyperphagia
Pertussis
Insulin Sensitivity

Stomach Neoplasms
Disease Of Adrenal Medulla
Neoplasm Metastasis
Metastatic Malignant Neoplasm To The Lymph Node
Carcinoma
Endoplasmic Reticulum Stress
Cachexia

Interacting Proteins

HTR1A

Pathways

Secretion
Insulin Secretion
Gastric Emptying
Glucose Homeostasis
Cell Proliferation
Transport
Hormone Secretion
Localization
Cell Death
Gastric Acid Secretion
Energy Homeostasis
Regeneration
Growth Hormone Secretion

Pathogenesis
Acid Secretion
Myoblast Migration
Osteoblast Development
Aging
Lung Development
Regulation Of Gene Expression

PTMs

Phosphorylation
Acylation
Cleavage

Amidation
Methylation
Iodination

Research Areas

GPCR

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPR39

References

PMID: 9441746 by McKee K.K., et al. Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors.

PMID: 18693759 by Storjohann L., et al. A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39.