Prosaposin receptor GPR37 Antibodies

AND GPR37 ELISA kits, Prosaposin receptor GPR37 Proteins

Many biological assays use antibodies to detect Prosaposin receptor GPR37, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prosaposin receptor GPR37 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prosaposin receptor GPR37 antibodies...

We validate the specificity of these antibodies to Prosaposin receptor GPR37 by testing them on tissues known to express GPR37 positively and negatively. Browse below to find the GPR37 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GPR37 Infographic by Boster Bio

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Anti-Prosaposin receptor GPR37 GPR37 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A05209
100ul

GPR37 Overview

Facts about Prosaposin receptor GPR37.

GPR37 3D structure. Source: alphafold

Prosaposin receptor GPR37 (GPR37)

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

Gene Information

Human
Gene Name:	GPR37
Uniprot:	O15354
Entrez:	2861

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

EDNRBL; Endothelin B receptor-like protein 1; ETBR-LP-1; G protein-coupled receptor 37 (endothelin receptor type B-like); GPR37; hET(B)R-LP; PAELR; PAELRETBR-LP-1; Parkin-associated endothelin receptor-like receptor; probable G-protein coupled receptor 37

Molecular Weight

Mass (kDA):
67.114 kDA

Genomic Context


Human

Location:	7q31.33
Sequence:	7; NC_000007.14 (124743885..124765792, complement)

Tissue Specificity

Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ).

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Parkinson Disease
Nerve Degeneration
Juvenile Parkinson's Disease
Secondary Parkinson Disease
Catalepsy
Neurodegenerative Disorders
Neurotoxicity Syndromes
Endoplasmic Reticulum Stress
Disease Of Adrenal Medulla
Leukemia, Myelocytic, Acute
Autistic Disorder
Tumor Angiogenesis

Myeloid Leukemia
Headache
Nervousness
Leukemia
Metrorrhagia
Autism Spectrum Disorders

Interacting Proteins

ADORA2A
GABBR1
HTR4
SLC3A2
SLC6A3

TMEM161A
TTYH1
YIF1A
YIF1B

Pathways

Cell Death
Pathogenesis
Dopamine Uptake
Macroautophagy
Developmental Process
Melanocyte Differentiation
Mitosis
Brain Development
Regulation Of Secretion
Localization

Methylation
Receptor Internalization
Angiogenesis
Autophagy
Secretion

PTMs

Phosphorylation

Methylation

Ubiquitination

Research Areas

GPCR

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPR37

References

PMID: 9339362 by Marazziti D., et al. Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library.

PMID: 9526070 by Donohue P.J., et al. A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system.