GPR18 Antibodies

AND GPR18 ELISA kits, GPR18 Proteins

Many biological assays use antibodies to detect GPR18, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GPR18 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GPR18 antibodies...

We validate the specificity of these antibodies to GPR18 by testing them on tissues known to express GPR18 positively and negatively. Browse below to find the GPR18 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GPR18 Infographic by Boster Bio

All GPR18 Products

Product

Figures

Specificity

Applications

Price

Anti-N-arachidonyl glycine receptor GPR18 Antibody

Human, Mouse, Rat

ICC, WB

$405
Cat # A09327
100ul

Anti-N-arachidonyl glycine receptor GPR18 Antibody

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$380
Cat # A09327-1
100ul

GPR18 (NM_001098200) Human Over-expression Lysate

Human

$628
Cat # LS002841
100 µg

GPR18 Overview

Facts about N-arachidonyl glycine receptor.

GPR18 3D structure. Source: alphafold

N-arachidonyl glycine receptor (GPR18)

However, conflicting results about the use of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant- based and synthetic cannabinoid agonists (PubMed:24762058).

The activity of this receptor is mediated by G proteins that inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system.

Gene Information

Human
Gene Name:	GPR18
Uniprot:	Q14330
Entrez:	2841

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

G protein-coupled receptor 18; GPCRW; GPR18; G-protein coupled receptor 18; NAGly Receptor; N-arachidonyl glycine receptor

Molecular Weight

Mass (kDA):
38.134 kDA

Genomic Context


Human

Location:	13q32.3
Sequence:	13; NC_000013.11 (99254713..99262498, complement)

Tissue Specificity

Expressed in midpiece of spermatozoon (at protein level) (PubMed:27572937). Most abundant in testis and spleen (PubMed:16844083). Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells (PubMed:16844083).

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.

Diseases

Pertussis
Nervousness
Peritonitis
Neoplasm Metastasis
Cell Transformation, Neoplastic
Metastatic Melanoma
Epstein-barr Virus Infections
Melanoma
Neurodegenerative Disorders
Endometrial Polyp
Endometriosis, Site Unspecified
Metastatic Malignant Neoplasm To Brain
Edema

Melanocytic Nevus
Patient Dependence On
Malignant Neoplasms
Neoplasms
Pain
Inflammation
Chronic Pain

Pathways

Cell Migration
Cell Proliferation
Programmed Cell Death
Cell Death
Localization
Conjugation

PTMs

Disulfide bond

Glycoprotein

Phosphoprotein

Research Areas

GPCR

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPR18

References

PMID: 9205118 by Gantz I., et al. Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis.

PMID: 16844083 by Kohno M., et al. Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.