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- Table of Contents
Facts about G-protein coupled receptor 135.
Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B probably through receptor heteromerization (PubMed:28827538). .
Human | |
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Gene Name: | GPR135 |
Uniprot: | Q8IZ08 |
Entrez: | 64582 |
Belongs to: |
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G-protein coupled receptor 1 family |
G protein-coupled receptor 135; GPR135; HUMNPIIY20; PAFR; probable G-protein coupled receptor 135
Mass (kDA):
51.736 kDA
Human | |
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Location: | 14q23.1 |
Sequence: | 14; NC_000014.9 (59452773..59465636, complement) |
Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Colocalizes with ARRB2/beta-arrestin-2 in the endosome.
PMID: 14623098 by Fredriksson R., et al. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.
PMID: 28827538 by Oishi A., et al. Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions.