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- Table of Contents
Facts about Probable G-protein coupled receptor 132.
May be involved in apoptosis. Functions in the G2/M checkpoint to delay mitosis.
Human | |
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Gene Name: | GPR132 |
Uniprot: | Q9UNW8 |
Entrez: | 29933 |
Belongs to: |
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G-protein coupled receptor 1 family |
G protein-coupled receptor 132; G2 accumulation protein; G2A; G2AG protein-coupled receptor G2A; GPR132; MGC99642; probable G-protein coupled receptor 132
Mass (kDA):
42.499 kDA
Human | |
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Location: | 14q32.33 |
Sequence: | 14; NC_000014.9 (105049395..105065430, complement) |
Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region.
Cell membrane; Multi-pass membrane protein. Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity).
PMID: 9770487 by Weng Z., et al. A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M.
PMID: 19855098 by Ogawa A., et al. Identification and analysis of two splice variants of human G2A generated by alternative splicing.