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- Table of Contents
Facts about Glucose-dependent insulinotropic receptor.
The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
Human | |
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Gene Name: | GPR119 |
Uniprot: | Q8TDV5 |
Entrez: | 139760 |
Belongs to: |
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G-protein coupled receptor 1 family |
G protein-coupled receptor 119; glucose-dependent insulinotropic receptor; GPCR2; GPR119; G-protein coupled receptor 119; G-protein coupled receptor 2; hGPCR2; MGC119957
Mass (kDA):
36.889 kDA
Human | |
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Location: | Xq26.1 |
Sequence: | X; NC_000023.11 (130384345..130385537, complement) |
Predominantly expressed in the pancreas, especially in the islets.
Cell membrane; Multi-pass membrane protein.
PMID: 14623098 by Fredriksson R., et al. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.
PMID: 15607732 by Soga T., et al. Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor.