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, No Gclids
GPNMB Antibodies
AND GPNMB ELISA kits, GPNMB Proteins
Many biological assays use antibodies to detect GPNMB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GPNMB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GPNMB antibodies...
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GPNMB Infographic by Boster Bio
All GPNMB Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK1251
96 wells/kit, with removable strips.
Cat # EK1251
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # EK1331
96 wells/kit, with removable strips.
Cat # EK1331
96 wells/kit, with removable strips.
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02439-1
100 μg/vial
Cat # A02439-1
100 μg/vial
GPNMB Overview
Facts about Transmembrane glycoprotein NMB.
Transmembrane glycoprotein NMB (GPNMB)
Could be a melanogenic enzyme. .
.
Gene Information
| Human | |
|---|---|
| Gene Name: | GPNMB |
| Uniprot: | Q14956 |
| Entrez: | 10457 |
Family
| Belongs to: |
|---|
| PMEL/NMB family |
Alternative Names
DC-HIL; glycoprotein (transmembrane) nmb; glycoprotein NMB; GPNMB; HGFIN; HGFINglycoprotein nmb-like protein; NMBosteoactivin; Osteoactivin; Transmembrane glycoprotein HGFIN; transmembrane glycoprotein NMB
Molecular Weight
Mass (kDA):
63.923 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p15.3 |
| Sequence: | 7; NC_000007.14 (23246766..23275110) |
Tissue Specificity
Up-regulated in various cancer cells, including in glioblastoma multiforme. Expressed in many melanoma cells, as well as in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level). Hardly detectable in healthy brain.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Melanosome membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Diseases
- Neoplasms
- Malignant Neoplasms
- Melanoma
- Neoplasm Metastasis
- Glaucoma
- Intraocular Pressure Disorder
- Inflammation
- Mammary Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Neoplasm Invasiveness
- Malignant Paraganglionic Neoplasm
- Iris Diseases
Interacting Proteins
- EGFR
Pathways
- Pathogenesis
- Osteoblast Differentiation
- Localization
- Cell Differentiation
- Regeneration
- Bone Resorption
- Cell Adhesion
- Cell Proliferation
- Glycosylation
- Transport
- Phagocytosis
- Cell Cycle
- Cell Growth
PTMs
- Glycosylation
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPNMB
bosterbio.com/bosterbio-gene-info-cards/GPNMB
References
PMID: 7814155 by Weterman M.A.J., et al. NMB, a novel gene, is expressed in low-metastatic human melanoma cell lines and xenografts.
PMID: 12609765 by Bandari P.S., et al. Hematopoietic growth factor inducible neurokinin-1 type: a transmembrane protein that is similar to neurokinin 1 interacts with substance P.