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BAIAP2 Antibodies
AND BAIAP2 ELISA kits, BAIAP2 Proteins
Many biological assays use antibodies to detect BAIAP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BAIAP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BAIAP2 antibodies...
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BAIAP2 Infographic by Boster Bio
All BAIAP2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M03306-1
100 µl
Cat # M03306-1
100 µl
BAIAP2 Overview
Facts about Brain-specific angiogenesis inhibitor 1-associated protein 2.
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2)
Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling.
Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth.
Gene Information
| Human | |
|---|---|
| Gene Name: | BAIAP2 |
| Uniprot: | Q9UQB8 |
| Entrez: | 10458 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BAI1-associated protein 2IRS-58; BAI-associated protein 2; BAP2; brain-specific angiogenesis inhibitor 1-associated protein 2; Fas ligand-associated factor 3; FLAF3; Insulin receptor substrate p53; Insulin receptor substrate p53/p58; Insulin receptor substrate protein of 53 kDa; IRSP53; IRSp53/58; Protein BAP2
Molecular Weight
Mass (kDA):
60.868 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.3 |
| Sequence: | 17; NC_000017.11 (81035131..81117434) |
Tissue Specificity
Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta.
Subcellular Localizations
Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
Diseases
- Protrusion
- Wiskott-aldrich Syndrome
- Tumor Angiogenesis
- Dentatorubral-pallidoluysian Atrophy
- Atrophy
- Neurodegenerative Disorders
- Malignant Neoplasms
- Tissue Adhesions
- Neoplasm Metastasis
- Neoplasms
- Nervousness
- Cell Invasion
- Nerve Degeneration
Interacting Proteins
- C19orf25
- CDC42
- Cdc42
- Enah
- EPS8
- Eps8
- KANK1
- NCKIPSD
- PRR13
- RAC1
Pathways
- Localization
- Cell Migration
- Angiogenesis
- Cell Adhesion
- Cell Motility
- Cell Proliferation
- Axon Guidance
- Rna Interference
- Transport
- Vesicle Transport
- Membrane Tubulation
- Dorsal Closure
- Actin Filament Branching
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BAIAP2
bosterbio.com/bosterbio-gene-info-cards/BAIAP2
References
PMID: 10343108 by Oda K., et al. Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1.
PMID: 10332026 by Okamura-Oho Y., et al. Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate.