GNPTAB Antibodies

AND GNPTAB ELISA kits, GNPTAB Proteins

Many biological assays use antibodies to detect GNPTAB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GNPTAB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GNPTAB antibodies...

We validate the specificity of these antibodies to GNPTAB by testing them on tissues known to express GNPTAB positively and negatively. Browse below to find the GNPTAB antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GNPTAB Infographic by Boster Bio

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GNPTAB (NM_024312) Human Over-expression Lysate

Human

$960
Cat # LS079158
100 µg

GNPTAB Overview

Facts about N-acetylglucosamine-1-phosphotransferase subunits alpha/beta.

GNPTAB 3D structure. Source: alphafold

N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB)

Catalyzes the formation of mannose 6-phosphate (M6P) mark on high mannose type oligosaccharides from the Golgi apparatus. M6P residues are needed to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.

Gene Information

Human
Gene Name:	GNPTAB
Uniprot:	Q3T906
Entrez:	79158

Family

Belongs to:

stealth family

Alternative Names

DKFZp762B226; GlcNAc phosphotransferase; glucosamine (UDP-N-acetyl)-lysosomal-enzyme N-acetylglucosamine phosphotransferase; GNPTA; ICD; KIAA1208; MGC4170; N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits; stealth protein GNPTAB; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosamine

Molecular Weight

Mass (kDA):
143.622 kDA

Genomic Context


Human

Location:	12q23.2
Sequence:	12; NC_000012.12 (101745499..101830959, complement)

Tissue Specificity

Expressed in the heart, whole brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Subcellular Localizations

[N-acetylglucosamine-1-phosphotransferase subunit alpha]: Golgi apparatus membrane; Single-pass type I membrane protein.; [N-acetylglucosamine-1-phosphotransferase subunit beta]: Golgi apparatus membrane; Single-pass type II membrane protein.

Diseases

Mucolipidoses
Type Ii Mucolipidosis
Stuttering
Lysosomal Storage Diseases
Pseudo-hurler Polydystrophy
Speech Disorders
Pfaundler-hurler Syndrome
Mutation, Out-of-frame
Hereditary Diseases
Rickets
Storage Disease

Neuropathology Disease
Retinal Degeneration
Growth Retardation
Lung Diseases
Dyslexia
Fetal Growth Retardation

Interacting Proteins

AEN
FAM90A1
PSMA1
STAMBPL1

Pathways

Transport
Secretion
Secretory Pathway
Localization
Translation
Secretion Of Lysosomal Enzymes
Intracellular Transport
Constitutive Secretory Pathway
Operant Conditioning
Macrophage Differentiation

Mrna Splicing
Response To Cholesterol
Bone Resorption
Excretion

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GNPTAB

References

PMID: 16200072 by Tiede S., et al. Mucolipidosis II is caused by mutations in GNPTA encoding the alpha/beta GlcNAc-1-phosphotransferase.

PMID: 16120602 by Kudo M., et al. The alpha- and beta-subunits of the human UDP-N- acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1- phosphotransferase are encoded by a single cDNA.