GNL3 Antibodies

Guanine nucleotide-binding protein-like 3 (GNL3)

May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).

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Gene Information

Human
Gene Name:	GNL3
Uniprot:	Q9BVP2
Entrez:	26354

Family

Belongs to:
TRAFAC class YlqF/YawG GTPase family

Alternative Names

C77032; E2IG3NNP47; estradiol-induced nucleotide binding protein; GNL3; guanine nucleotide binding protein-like 3 (nucleolar); guanine nucleotide-binding protein-like 3; MGC800; Novel nucleolar protein 47; NSE2-induced gene 3 protein; Nucleolar GTP-binding protein 3; Nucleostemin

Molecular Weight

Mass (kDA):
61.993 kDA

Genomic Context

Human
Location:	3p21.1
Sequence:	3; NC_000003.12 (52685920..52694497)

Tissue Specificity

Increased levels in lung tissue in cancer patients.

Subcellular Localizations

Nucleus. Nucleus, nucleolus. Shuttles between the nucleus and nucleolus.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Cell Transformation, Neoplastic
• Malignant Paraganglionic Neoplasm
• Malignant Squamous Cell Neoplasm
• Hyperplasia
• Neoplasm Metastasis
• Prostatic Neoplasms
• Malignant Neoplasm Of Prostate
• Esophageal Neoplasms
• Malignant Neoplasm Of Lung
• Lymphatic Metastasis

• Mammary Neoplasms
• Squamous Cell Carcinoma Of Esophagus
• Metastatic Malignant Neoplasm To The Lymph Node
• Neoplasms, Experimental
• Lymphoma
• Basal Cell Carcinoma
• Malignant Neoplasm Of Stomach

Interacting Proteins

• AGO2
• MDM2
• PPP2R5A
• STAT3
• TERT

Pathways

• Cell Cycle
• Cell Proliferation
• Cell Cycle Arrest
• Mitosis
• Localization
• S Phase
• Cell Differentiation
• Cell Growth
• Pathogenesis
• Aging
• Neurogenesis
• Interphase
• Oncogenesis

• Cell Death
• Regulation Of Cell Proliferation
• Cell Adhesion
• Transport
• Cell Cycle Checkpoint
• Protein Targeting
• Cytoskeleton Organization

PTMs

• Ubiquitination

• Sumoylation

• Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GNL3

Boster Bio: Best Uses Of The Anti-GNL3 Marker

It can be difficult for new users to get started with the BosterBio: Best Uses Of Anti-GNL3 Marker. These are some of the ways that you can use GNL3 Marker. This article will discuss each of these options. Continue reading for more information! Don't forget sharing this article to your colleagues and classmates. You can also use Boster Bio: Best Uses Of The GNL3 Marker in your research!

Boster Bio Anti GNL3 Marker

There are many biological tests that use the GNL3 gene. These antibodies react with a wide range animal samples, and can be monoclonal (or polyclonal) in most cases. Boster Bio has created antibodies that specifically detect GNL3 protein. They have used both mice and rabbits to test their effectiveness. Antibodies are highly specific and can recognize samples from rats, mice, and humans.

Boster Bio: The GNL3 Marker

The GNL3 gene codes for the protein known as nucleostemin. This protein is found in the nucleus, and it appears to interact with the tumor suppressor, p53. It is also believed that it plays an important role in stem cells proliferation. Three transcript variants, each encoding two different isoforms for the GNL3 protein, have been identified. Boster Bio validates all its antibodies with known positive or negative samples.

Boster Bio's anti-GNL3 antibody (catalog number: A03283-2), has been tested in ELISA and Flow Cymetry assays. It reacts with human, mouse, and rat samples. It is also available as a liquid in PBS. It has been used to detect GNL3 markers in many tissues, including the skin, brain, lung, and skin.

Boster Bio: Alternatives for the GNL3 Marker

The GNL3 gene, which has been linked to several neurodegenerative disorders, was recently recognized as a novel candidate for genetic testing. Recent research has shown that patients with neurodegenerative conditions are at higher risk of developing Alzheimer's disease. For those with an inherited mutation of chromosome 9, the GNL3 gene is associated to an increased risk for Alzheimer's disease.