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Protein FAM162A Antibodies
AND FAM162A ELISA kits, Protein FAM162A Proteins
Many biological assays use antibodies to detect Protein FAM162A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein FAM162A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein FAM162A antibodies...
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FAM162A Overview
Facts about Protein FAM162A.
Protein FAM162A (FAM162A)
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (for instance, CASP9) and causing mitochondrial permeability transition.
May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation into the nucleusnonetheless, the involvement of caspases has been reported conflictingly. .
Gene Information
| Human | |
|---|---|
| Gene Name: | FAM162A |
| Uniprot: | Q96A26 |
| Entrez: | 26355 |
Family
| Belongs to: |
|---|
| UPF0389 family |
Alternative Names
chromosome 3 open reading frame 28; E2IG5C3orf28growth and transformation-dependent protein; E2-induced gene 5 protein; family with sequence similarity 162, member A; HGTD-P; HIF-1 alpha-responsive proapoptotic molecule
Molecular Weight
Mass (kDA):
17.342 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q21.1 |
| Sequence: | 3; NC_000003.12 (122384182..122412334) |
Subcellular Localizations
Membrane; Single-pass membrane protein. Mitochondrion.
Diseases
- Malignant Neoplasms
- Hypoxia
- Uterine Cervical Neoplasm
- Malignant Tumor Of Cervix
- Neoplasms
- Hypoxia-ischemia, Brain
- Stomach Neoplasms
- Neuroblastoma
- Chromosomal Deletion
- Adenocarcinoma
- Malignant Neoplasm Of Prostate
- Adenoma
Interacting Proteins
- HSP90AB1
- VDAC2
Pathways
- Cell Death
- Cell Proliferation
- Mitochondrial Translocation
- Mitochondrial Fission
- Angiogenesis
- Glycolysis
PTMs
- Phosphorylation
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FAM162A
bosterbio.com/bosterbio-gene-info-cards/FAM162A
References
PMID: 11085516 by Charpentier A.H., et al. Effects of estrogen on global gene expression: identification of novel targets of estrogen action.
PMID: 15082785 by Lee M.J., et al. Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway.