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- Table of Contents
Facts about Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7.
Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) which is required for adenylyl cyclase activity in the striatum (By similarity).
Human | |
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Gene Name: | GNG7 |
Uniprot: | O60262 |
Entrez: | 2788 |
Belongs to: |
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G protein gamma family |
FLJ00058; GNGT7; guanine nucleotide binding protein (G protein), gamma 7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Mass (kDA):
7.522 kDA
Human | |
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Location: | 19p13.3 |
Sequence: | 19; NC_000019.10 (2511219..2702694, complement) |
Expressed in a variety of tissues. Down- regulated in pancreatic and esophageal cancer.
Cell membrane; Lipid-anchor; Cytoplasmic side.
PMID: 9600093 by Shibata K., et al. Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer.
PMID: 18219292 by Ohta M., et al. Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer.