HCN4 Antibodies

AND HCN4 ELISA kits, HCN4 Proteins

Many biological assays use antibodies to detect HCN4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HCN4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HCN4 antibodies...

We validate the specificity of these antibodies to HCN4 by testing them on tissues known to express HCN4 positively and negatively. Browse below to find the HCN4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HCN4 Infographic by Boster Bio

All HCN4 Products

Product

Figures

Specificity

Applications

Price

Anti-HCN4 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A02235
100ul

Anti-HCN4 Antibody Picoband™

2 Citations

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A02235-1
100 μg/vial

HCN4 Overview

Facts about Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN4 3D structure. Source: alphafold

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4)

Hyperpolarization-activated ion channel with very slow activation and inactivation displaying weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat.

May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.

Gene Information

Human
Gene Name:	HCN4
Uniprot:	Q9Y3Q4
Entrez:	10021

Family

Belongs to:

potassium channel HCN family

Alternative Names

HCN4; hyperpolarization activated cyclic nucleotide-gated cation channel 4; hyperpolarization activated cyclic nucleotide-gated potassium channel 4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; SSS2

Molecular Weight

Mass (kDA):
129.042 kDA

Genomic Context


Human

Location:	15q24.1
Sequence:	15; NC_000015.10 (73319859..73368958, complement)

Tissue Specificity

Highly expressed in thalamus, testis and in heart, both in ventricle and atrium. Detected at much lower levels in amygdala, substantia nigra, cerebellum and hippocampus.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Cardiac Arrhythmia
Bradycardia
Hypertrophy
Nervousness
Heart Failure
Heart Diseases
Angina Pectoris
Sinus Node Dysfunction (disorder)
Epilepsy
Sick Sinus Syndrome
Myocardial Infarction
Cardiac Fibrillation

Atrial Fibrillation
Cardiac Hypertrophy
Chronic Stable Angina
Ischemia
Left Ventricular Hypertrophy
Cardiomyopathies

Pathways

Localization
Cardiac Conduction
Heart Development
Reverse Transcription
Secretion
Membrane Hyperpolarization
Transport
Response To Camp
Aging
Reflex
Cell Cycle
Cell Differentiation
Regulation Of Heart Rate

Synaptic Transmission
Regeneration
Pathogenesis
Heart Formation
Translation
Cognition
Cell Proliferation

PTMs

Phosphorylation
Biotinylation

Glycosylation
Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HCN4

References

PMID: 10228147 by Ludwig A., et al. Two pacemaker channels from human heart with profoundly different activation kinetics.

PMID: 10430953 by Seifert R., et al. Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis.

2 Publications of Boster HCN4 Antibodies & ELISA Kits

PubMed ID: 10.3892/mmr.2011.455, Spironolactone diminishes spontaneous ventricular premature beats by reducing HC...
PubMed ID: 10.1093/abbs/gmx026, Age-dependent down-regulation of hyperpolarization-activated cyclic nucleotide-g...

*More publications can be found for each product on its corresponding product page