GNAS Antibodies

AND GNAS ELISA kits, GNAS Proteins

Many biological assays use antibodies to detect GNAS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GNAS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GNAS antibodies...

We validate the specificity of these antibodies to GNAS by testing them on tissues known to express GNAS positively and negatively. Browse below to find the GNAS antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GNAS Infographic by Boster Bio

All GNAS Products

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Product

Figures

Specificity

Applications

Price

Anti-Protein ALEX GNAS Antibody

Human, Mouse, Rat

IP, IF, ICC, WB

$405
Cat # A01243
100ul

G protein alpha S (GNAS) (NM_080426) Human Recombinant Protein

$1062
Cat # PROTP63092
20 µg

Anti-GNAS Antibody (N-Term)

Human, Mouse, Rat

$299
Cat # M01243
50 µl

Anti-G protein alpha S (GNAS) Mouse Monoclonal Antibody [Clone ID: OTI13D7]

Human

IHC, WB

$523
Cat # M01243-1
100 µl

GNAS Overview

Facts about Neuroendocrine secretory protein 55.

GNAS 3D structure. Source: alphafold

Neuroendocrine secretory protein 55 (GNAS)

Guanine nucleotide-binding proteins (G proteins) be the transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665).

GNAS functions downstream of many GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).

Gene Information

Human
Gene Name:	GNAS
Uniprot:	O95467
Entrez:	2778

Family

Belongs to:

NESP55 family

Alternative Names

Adenylate cyclase-stimulating G alpha protein; AHO; Alternative gene product encoded by XL-exon; Extra large alphas protein; GNAS complex locus; GNAS1GSA; GNASXL; GPSAC20orf45; GSP; guanine nucleotide binding protein (G protein), alpha stimulating activitypolypeptide 1; guanine nucleotide regulatory protein; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; MGC33735; NESP; NESP55; neuroendocrine secretory protein; PHP1A; PHP1B; PHP1C; POH; protein ALEX; SCG6; secretogranin VI; XLalphas

Molecular Weight

Mass (kDA):
28.029 kDA

Genomic Context


Human

Location:	20q13.32
Sequence:	20; NC_000020.11 (58839681..58911196)

Subcellular Localizations

Cytoplasmic vesicle, secretory vesicle. Secreted. Neuroendocrine secretory granules.

Diseases

Pseudohypoparathyroidism
Polyostotic Fibrous Dysplasia
Neoplasms
Dysplasia
Mccune-albright Syndrome
Fibrous Dysplasia
Obesity
Pituitary Diseases
Adenoma
Malignant Neoplasms
Osteitis Fibrosa Disseminata
Hypocalcemia

Pseudopseudohypoparathyroidism
Pseudohypoparathyroidism, Type Ia
Pituitary Neoplasms
Dwarfism
Hyperphosphatemia
Heterotopic Ossification

Pathways

Methylation
Pathogenesis
Dna Methylation
Ossification
Secretion
Localization
Cell Cycle
Oncogenesis
Bone Resorption
Spermatogenesis
Cell Differentiation
Cell Proliferation
Excretion

Osteoblast Differentiation
Oogenesis
Secretory Pathway
Fertilization
Pigmentation
Bone Development
Cortisol Secretion

PTMs

Methylation
Phosphorylation

Reduction
Demethylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GNAS

References

PMID: 9860993 by Hayward B.E., et al. Bidirectional imprinting of a single gene: human GNAS1 encodes distinct maternally, paternally and biallelically derived proteins.

PMID: 10749992 by Hayward B.E., et al. An imprinted antisense transcript at the human GNAS1 locus.