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GFI1B Antibodies
AND GFI1B ELISA kits, GFI1B Proteins
Many biological assays use antibodies to detect GFI1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GFI1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GFI1B antibodies...
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GFI1B Overview
Facts about Zinc finger protein Gfi-1b.
Zinc finger protein Gfi-1b (GFI1B)
Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.
Transcriptional repressor or activator based on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and so, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate.
Gene Information
| Human | |
|---|---|
| Gene Name: | GFI1B |
| Uniprot: | Q5VTD9 |
| Entrez: | 8328 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
growth factor independent 1B transcription repressor; Growth factor independent protein 1B; Potential regulator of CDKN1A translocated in CML; translocated inCML); zinc finger protein Gfi-1b
Molecular Weight
Mass (kDA):
37.492 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.13 |
| Sequence: | 9; NC_000009.12 (132945531..132991697) |
Tissue Specificity
Expressed in bone marrow and fetal liver, but also detectable in fetal spleen, fetal thymus, and testes. Detected in hematopoietic stem cells, erythroblasts, and megakaryocytes. Overexpressed in bone marrow of patients with erythroleukemia and megakaryocytic leukemia as well as in their corresponding leukemic cell lines, and markedly repressed in severe aplastic anemia (SAA).
Subcellular Localizations
Nucleus.
Diseases
- Leukemia
- Malignant Neoplasms
- Myeloid Leukemia
- Lymphoma
- Leukemia, Myelocytic, Acute
- Cell Transformation, Neoplastic
- Myeloid Leukemia, Chronic
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Carcinoma
- Hematological Disease
- T-cell Lymphoma
Interacting Proteins
- CENPJ
- JAG2
- NELL2
Pathways
- Cell Cycle
- Cell Differentiation
- Cell Development
- Chromatin Remodeling
- Cell Proliferation
- Megakaryocyte Differentiation
- Megakaryocyte Development
- Methylation
- Rna Interference
- Cell Adhesion
- Cell Activation
- Programmed Cell Death
- Neutrophil Differentiation
PTMs
- Biotinylation
- Acetylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GFI1B
bosterbio.com/bosterbio-gene-info-cards/GFI1B
References
PMID: 9878267 by Roedel B., et al. The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases.
PMID: 15280509 by Huang D.Y., et al. GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene.