GCNT3 Antibodies

AND GCNT3 ELISA kits, GCNT3 Proteins

Many biological assays use antibodies to detect GCNT3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GCNT3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GCNT3 antibodies...

We validate the specificity of these antibodies to GCNT3 by testing them on tissues known to express GCNT3 positively and negatively. Browse below to find the GCNT3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GCNT3 Infographic by Boster Bio

All GCNT3 Products

Product

Figures

Specificity

Applications

Price

Anti-GCNT3 Antibody

Human

$405
Cat # A08909
100ul

Anti-GCNT3 Antibody

Human

ELISA, IF, IHC

$380
Cat # A08909-1
100ul

GCNT3 (NM_004751) Human Over-expression Lysate

Human

$628
Cat # LS009245
100 µg

GCNT3 Overview

Facts about Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3.

GCNT3 3D structure. Source: alphafold

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3)

Glycosyltransferase that can synthesize all famous mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis.

Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. .

Gene Information

Human
Gene Name:	GCNT3
Uniprot:	O95395
Entrez:	9245

Family

Belongs to:

glycosyltransferase 14 family

Alternative Names

beta-1,3-galactosyl-O-glycosyl-glycoproteinbeta-1,6-N-acetylglucosaminyltransferase 3; beta1,6GlcNAc-transferase; beta1,6-N-acetylglucosaminyltransferase-M; C2/4GnTGNTM; C24GNT; C2GnT2; C2GNTM; C2GnT-M; C2GnT-mucin type; Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase; EC 2.4.1.102; EC 2.4.1.150; glucosaminyl (N-acetyl) transferase 3, mucin type; hC2GnT-M; mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase

Molecular Weight

Mass (kDA):
50.864 kDA

Genomic Context


Human

Location:	15q22.2
Sequence:	15; NC_000015.10 (59611783..59622723)

Tissue Specificity

Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced.

Subcellular Localizations

Golgi apparatus membrane; Single-pass type II membrane protein.

Diseases

Nematode Infections
Hyperplasia
Metabolic Syndrome X
Decreased Immunologic Activity [pe]
Trichostrongyloidiasis
Lung Diseases
Cattle Diseases

Trematode Infections

Pathways

Glycosylation
Protein Glycosylation
Sensitization
Cell Proliferation
Cell Differentiation
Immune Response
Pathogenesis

Localization
Fucosylation

PTMs

Glycosylation

Research Areas

Mucosal Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GCNT3

References

PMID: 9915862 by Yeh J.-C., et al. Molecular cloning and expression of a novel beta-1, 6-N- acetylglucosaminyltransferase that forms core 2, core 4, and I branches.

PMID: 9988682 by Schwientek T., et al. Control of O-glycan branch formation. Molecular cloning of human cDNA encoding a novel beta1,6-N-acetylglucosaminyltransferase forming core 2 and core 4.