GCLC Antibodies

AND GCLC ELISA kits, GCLC Proteins

Many biological assays use antibodies to detect GCLC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GCLC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GCLC antibodies...

We validate the specificity of these antibodies to GCLC by testing them on tissues known to express GCLC positively and negatively. Browse below to find the GCLC antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GCLC Infographic by Boster Bio

All GCLC Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-GCLC Antibody Picoband®

4 Citations

Human, Mouse, Rat

IHC, WB

$370
Cat # PA1492
100 μg/vial

Anti-GCLC Antibody Picoband®

4 Citations 5 Q&As

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$370
Cat # PB9201
100 μg/vial

Anti-GCLC Rabbit Monoclonal Antibody

3 Citations

Human, Rat

$370
Cat # M01722
100 μl

Anti-GCLC Mouse Monoclonal Antibody [Clone ID: OTI1A3]

1 Citations

Human, Monkey, Mouse, Rat

IHC, WB

$523
Cat # M01722-1
100 µl

Anti-GCLC Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, WB

$370
Cat # A01722
100 μg/vial

GCLC Overview

Facts about Glutamate--cysteine ligase catalytic subunit.

GCLC 3D structure. Source: alphafold

Glutamate--cysteine ligase catalytic subunit (GCLC)

Gene Information

Human
Gene Name:	GCLC
Uniprot:	P48506
Entrez:	2729

Family

Belongs to:

glutamate--cysteine ligase type 3 family

Alternative Names

EC 6.3.2.2; gamma-ECS; Gamma-glutamylcysteine synthetase; GCS heavy chain; GCS; GLCL; GLCLCGCL; glutamate--cysteine ligase catalytic subunit; glutamate-cysteine ligase, catalytic subunit

Molecular Weight

Mass (kDA):
72.766 kDA

Genomic Context


Human

Location:	6p12.1
Sequence:	6; NC_000006.12 (53497341..53545101, complement)

Diseases

Malignant Neoplasms
Liver Carcinoma
Hepatotoxicity
Liver Diseases
Inflammation
Injury To Liver
Neoplasms
Diabetes Mellitus
Infarction
Lung Diseases
Steatohepatitis
Adenocarcinoma

Inflammatory Response
Malignant Neoplasm Of Lung
Cardiovascular Diseases
Schizophrenia
Fatty Liver
Fibrosis
Steatosis

Pathways

Cell Death
Pathogenesis
Response To Oxidative Stress
Cell Proliferation
Aging
Conjugation
Inflammatory Response
Cell Cycle
Localization
Transport
Translation
Neuroprotection
Cellular Homeostasis

Transsulfuration
Proestrus
Gastric Emptying
Excretion
Immune Response
Proteolysis
Cell Cycle Arrest

PTMs

Phosphorylation
Reduction
Oxidation
Cleavage

Glutathionylation
Sumoylation
Methylation
Myristoylation

Research Areas

Cell Biology
Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GCLC

References

PMID: 1350904 by Gipp J.J., et al. Cloning and nucleotide sequence of a full-length cDNA for human liver gamma-glutamylcysteine synthetase.

PMID: 7726839 by Mulcahy R.T., et al. Identification of a putative antioxidant response element in the 5'- flanking region of the human gamma-glutamylcysteine synthetase heavy subunit gene.

5 Publications of Boster GCLC Antibodies & ELISA Kits

PubMed ID: 10.3390/ijms21134679, Aldosterone Induces DNA Damage and Activation of Nrf2 Mainly in Tubuli of Mouse ...
PubMed ID: 10.1155/2021/6688708, Fucoxanthin Prevents 6-OHDA-Induced Neurotoxicity by Targeting Keap1
PubMed ID: -, Zhilei Mao,Shushu Li,Lina Zhang,Mengmeng Yao,Zhu Zhou,Minjian Chen,"The mTOR/GCL...
PubMed ID: 27630691, Electroacupuncture alleviates cerebral ischemia and reperfusion injury via modul...
PubMed ID: 26339340, Bone marrow mesenchymal stem cells protect against bleomycin-induced pulmonary f...

*More publications can be found for each product on its corresponding product page