Grancalcin Antibodies

Grancalcin (GCA)

Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.

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Gene Information

Human
Gene Name:	GCA
Uniprot:	P28676
Entrez:	25801

Family

Belongs to:
No superfamily

Alternative Names

EF-hand calcium-binding protein; grancalcin, EF-hand calcium binding protein; grancalcin, penta-EF-hand protein

Molecular Weight

Mass (kDA):
24.01 kDA

Genomic Context

Human
Location:	2q24.2
Sequence:	2; NC_000002.12 (162318763..162377225)

Tissue Specificity

Detected in neutrophils and macrophages (at protein level). Highly expressed in bone marrow.

Subcellular Localizations

Cytoplasm. Cytoplasmic granule membrane; Peripheral membrane protein; Cytoplasmic side. Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels.

Diseases

• Giant Cell Arteritis
• Arteritis
• Polymyalgia Rheumatica
• Vasculitis
• Malignant Neoplasms
• Inflammation
• Neoplasms
• Carcinoma
• Headache
• Stomach Neoplasms
• Adenocarcinoma
• Blind Vision

• Temporal Arteritis
• Claudication (finding)
• Ischemia
• Visual Impairment
• Malignant Squamous Cell Neoplasm
• Esophageal Neoplasms
• Pain

Interacting Proteins

• MAGEA8

Pathways

• Pathogenesis
• Translation
• Mating
• Transport
• Inflammatory Response
• Methylation
• Localization
• Excretion
• Immune Response
• Conjugation
• Angiogenesis
• Secretion
• Cell Adhesion

• Cell Proliferation
• Cell Growth
• Cell Migration
• Fermentation
• Trna Aminoacylation
• Oncogenesis
• Response To Stress

PTMs

• Methylation
• Phosphorylation
• Cleavage
• Nitration
• Biotinylation

• Oxidation
• Reduction
• Deamination
• Acetylation
• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GCA

Best Uses Of The GCA Marker

This biography reveals a lot about Steve Boster. Learn about his family and work. We also provide information about his life and where he was born. This biography of Steve Boster is a must-read. Keep reading to learn more information about Steve Boster. You will be impressed by what you find out! This biography will help to make an informed decision about buying a GCA marker.

History of Steve Boster

Steve Boster was also a successful carpenter. He was also an avid sports enthusiast. His passion for football, basketball, and auto racing was unmatched. He was always there for him in any weather, even below-freezing. Steve was generous with his friends, whom he considered to be his family. He was a generous man who would not turn down a friend.

His work

Despite all the medical advances, it is still not possible to identify biomarkers that validate GCA. The new marker could still be used as an initial diagnostic tool for GCA sufferers. It may be used to help patients classify their disease according to the severity of their condition and whether they are most likely to experience relapses. Its diagnostic value is yet to be determined. Here's a summary about Boster’s work on the GCA marker.