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GAS8 Antibodies
AND GAS8 ELISA kits, GAS8 Proteins
Many biological assays use antibodies to detect GAS8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GAS8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GAS8 antibodies...
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GAS8 Overview
Facts about Dynein regulatory complex subunit 4.
Dynein regulatory complex subunit 4 (GAS8)
Part of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary/flagellar motility which maintains the integrity and alignment of the distal axoneme and modulates microtubule sliding in motile axonemes. Plays an essential part in the assembly of the N-DRC linker (By similarity).
Plays dual roles at both the primary (or non-motile) cilia to modulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning (PubMed:26387594, PubMed:27120127, PubMed:27472056).
Gene Information
| Human | |
|---|---|
| Gene Name: | GAS8 |
| Uniprot: | O95995 |
| Entrez: | 2622 |
Family
| Belongs to: |
|---|
| DRC4 family |
Alternative Names
GAS-11; GAS11MGC138326; GAS-8; growth arrest specific 11; growth arrest-specific 11; growth arrest-specific 8; Growth arrest-specific protein 11; growth arrest-specific protein 8
Molecular Weight
Mass (kDA):
56.356 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q24.3 |
| Sequence: | 16; NC_000016.10 (90019629..90044971) |
Tissue Specificity
Expressed in respiratory epithelial cells (at protein level) (PubMed:26387594). Expressed in the heart, skeletal muscle, pancreas, liver, brain, trachea and lung. Weakly or not expressed in placenta and kidney (PubMed:9790751).
Subcellular Localizations
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Golgi apparatus. Cell projection, cilium. Cytoplasm, cytoskeleton, flagellum axoneme. Associates with microtubules (PubMed:10969087). Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa (By similarity).
Diseases
- Neoplasms
- Growth Arrest
- Malignant Neoplasms
- Influenza
- Malignant Neoplasm Of Prostate
- Cell Transformation, Neoplastic
- African Trypanosomiasis
- Malignant Neoplasm Of Breast
- Carcinoma
- Prostatic Neoplasms
Interacting Proteins
- GRIPAP1
Pathways
- Localization
- Cell Motility
- Transport
- Cell Proliferation
- Mitosis
- Spermatogenesis
- Cytokinesis
- Cell Division
- Swimming
- Sperm Motility
- Cell Cycle
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GAS8
bosterbio.com/bosterbio-gene-info-cards/GAS8
References
PMID: 9790751 by Whitmore S.A., et al. Characterization and screening for mutations of the growth arrest- specific 11 (GAS11) and C16orf3 genes at 16q24.3 in breast cancer.
PMID: 10969087 by Hill K.L., et al. T lymphocyte-triggering factor of African trypanosomes is associated with the flagellar fraction of the cytoskeleton and represents a new family of proteins that are present in several divergent eukaryotes.