Glycine--tRNA ligase Antibodies

AND GARS1 ELISA kits, Glycine--tRNA ligase Proteins

Many biological assays use antibodies to detect Glycine--tRNA ligase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Glycine--tRNA ligase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Glycine--tRNA ligase antibodies...

We validate the specificity of these antibodies to Glycine--tRNA ligase by testing them on tissues known to express GARS1 positively and negatively. Browse below to find the GARS1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GARS1 Infographic by Boster Bio

All GARS1 Products

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Product

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Specificity

Applications

Price

Human GARS Recombinant Protein

SDS-PAGE

$265
Cat # PROTP41250-1
Starting from 10ug

Anti-GARS1 Mouse Monoclonal Antibody [Clone ID: OTI4G4]

+12

Human, Mouse, Rat

IHC

$523
Cat # M04618-1
100 µl

GARS1 (NM_002047) Human Over-expression Lysate

Human

$628
Cat # LS002617
100 µg

Anti-GARS1 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A04618-2
100 μg/vial

GARS1 Overview

Facts about Glycine--tRNA ligase.

GARS1 3D structure. Source: alphafold

Glycine--tRNA ligase (GARS1)

Catalyzes the ligation of glycine into the 3'-end of its cognate tRNA. Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of two ATPs.

Gene Information

Human
Gene Name:	GARS1
Uniprot:	P41250
Entrez:	2617

Family

Belongs to:

class-II aminoacyl-tRNA synthetase family

Alternative Names

Glycine--tRNA ligase

Molecular Weight

Mass (kDA):
83.166 kDA

Genomic Context


Human

Location:	7p14.3
Sequence:	7; NC_000007.14 (30594735..30634033)

Tissue Specificity

Widely expressed, including in brain and spinal cord.

Subcellular Localizations

Cytoplasm. Mitochondrion. Cell projection, axon. Secreted. Secreted, extracellular exosome. In transfected COS7 cells, not detected in mitochondria, nor in Golgi apparatus (PubMed:17035524). Secreted by motor neuron, possibly through the exosome pathway (By similarity).

Diseases

Charcot-Marie-Tooth disease 2D (CMT2D)

Interacting Proteins

Gars

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GARS1

References

PMID: 7962006 by Shiba K., et al. Human glycyl-tRNA synthetase. Wide divergence of primary structure from bacterial counterpart and species-specific aminoacylation.

PMID: 7753621 by Williams J.H., et al. Cloning, sequencing and bacterial expression of human glycine tRNA synthetase.