Gigaxonin Antibodies

AND GAN ELISA kits, Gigaxonin Proteins

Many biological assays use antibodies to detect Gigaxonin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Gigaxonin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Gigaxonin antibodies...

We validate the specificity of these antibodies to Gigaxonin by testing them on tissues known to express GAN positively and negatively. Browse below to find the GAN antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GAN Infographic by Boster Bio

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GAN Overview

Facts about Gigaxonin.

GAN 3D structure. Source: alphafold

Gigaxonin (GAN)

Probable cytoskeletal component that directly or indirectly has an significant role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal survival and maintenance.

Gene Information

Human
Gene Name:	GAN
Uniprot:	Q9H2C0
Entrez:	8139

Family

Belongs to:

No superfamily

Alternative Names

FLJ38059; GAN1KLHL16Kelch-like protein 16; giant axonal neuropathy (gigaxonin); gigaxonin

Molecular Weight

Mass (kDA):
67.638 kDA

Genomic Context


Human

Location:	16q23.2
Sequence:	16; NC_000016.10 (81314962..81390809)

Tissue Specificity

Expressed in brain, heart and muscle.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton.

Diseases

Neoplasms
Giant Axonal Neuropathy 1
Nervousness
Pain
Gastrointestinal Stromal Tumors
Neurodegenerative Disorders
Plexosarcoma
Hepatitis
Stasis
Stomach Neoplasms
Stromal Neoplasm
Gastrointestinal Neoplasms

Malignant Neoplasms
Depressive Disorder
Cytomegalovirus Infections
Autonomic Nervous System Disorders
Inflammation
Parotid Neoplasms

Interacting Proteins

MAP1B
NUDCD3
TBCB
UBA1

Pathways

Pathogenesis
Transport
Localization
Cell Adhesion
Menstruation
Tropism
Swimming
Cell Proliferation
Regeneration
Dna Replication
Innervation
Fertilization
Immune Response

Diuresis
Inflammatory Response
Cell Death
Cell Migration
Protein Targeting
Fibroblast Proliferation
Intermediate Filament Organization

PTMs

Phosphorylation
Reduction
Cleavage

Amidation
Acylation
Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GAN

References

PMID: 11062483 by Bomont P., et al. The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy.

PMID: 12147674 by Ding J., et al. Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin.