GAK Antibodies

Cyclin-G-associated kinase (GAK)

Associates with cyclin G and CDK5.

Appears to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells.

Expression oscillates slightly during the cell cycle, peaking at G1. .

Gene Information

Human
Gene Name:	GAK
Uniprot:	O14976
Entrez:	2580

Family

Belongs to:
protein kinase superfamily

Alternative Names

Auxillin 2; cyclin G associated kinase; cyclin-G-associated kinase; EC 2.7.11.1; FLJ16629; FLJ40395; GAK; MGC99654

Molecular Weight

Mass (kDA):
143.191 kDA

Genomic Context

Human
Location:	4p16.3
Sequence:	4; NC_000004.12 (849276..932330, complement)

Tissue Specificity

Ubiquitous. Highest in testis.

Subcellular Localizations

Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network. Cell junction, focal adhesion. Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.

Diseases

• Parkinson Disease
• Neoplasms
• Malignant Neoplasms
• Malignant Paraganglionic Neoplasm
• Melanoma
• Hepatitis
• Hepatitis C
• Malignant Neoplasm Of Prostate
• Virus Diseases
• Alzheimer's Disease
• Cholangiocarcinoma
• Malignant Bone Neoplasm

• Drug-induced Liver Injury
• Abscess
• Down Syndrome
• Malignant Tumor Of Cervix
• Sarcoma
• Carcinoma
• Fibrosis

Interacting Proteins

• ATP13A2
• HSPA8
• LRRK2

Pathways

• Endocytosis
• Clathrin-mediated Endocytosis
• Pathogenesis
• Receptor-mediated Endocytosis
• Mitosis
• Localization
• Cell Proliferation
• Cell Cycle
• Rna Interference
• Transport
• Hyperphosphorylation
• Secretory Pathway
• G1 Phase

• Aging
• Neurogenesis
• Metaphase
• Membrane Budding
• Chromosome Segregation
• Cell Cycle Arrest
• Fermentation

PTMs

• Phosphorylation

• Dephosphorylation

• Cleavage

Research Areas

• Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GAK

Best Uses Of The GAK Marker - Steven Boster

The following article contains some biographical information regarding Steven Boster. Here you will find information about his life, family, and hobbies. It will also discuss some of his philosophies. Continue reading to learn about the man behind the product. There are many reasons to use the GAK marker and this article will explore some of them. Here is a brief description of Boster’s background. We hope you enjoy it.

History of Steven Boster

Steve Boster (57), died on June 6, 2022, in Madison, WI. He was born Joliet, IL. Evelyn Meier Boster and James Meier Boster were his parents. He had been a sales manager in retail for many years. He was also a U.S. Army Veteran. He was a Concordia Hall member in Staunton. His survivors include Crystal Boster (and Natosha) Peck, his 6 grandchildren, Jack Boster (4 Brothers), and Lisa Milton (and many nieces & nephews).

Steve was devoted to his family above all. He loved his family more than anyone and was proud of them. He was also an avid sports fan. His car would break down at 2 AM and he would be the one to help. He even drove to the rescue of friends in dire need in below-freezing conditions. Steve's history includes many important landmarks. If you're looking for details on Steven Boster, you can use the resources below.

His family

The GAK Marker is a great tool to play the game of "Him & His Family". To teach the stories of Enos/Abinadi, Alma/Younger, and other characters in Book of Mormon with your children, you can create a timeline and use GAK photos. You can ask your children to help prepare the game by helping to find pictures in the meetinghouse library or by choosing appropriate songs. You can also help your children research the scriptures on the back of the GAK pictures. They can then retell the story of the picture by sharing scriptures with you.