GADD45B Antibodies

Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

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Gene Information

Human
Gene Name:	GADD45B
Uniprot:	O75293
Entrez:	4616

Family

Belongs to:
GADD45 family

Alternative Names

DKFZp566B133; GADD45BETA; growth arrest and DNA damage-inducible protein GADD45 beta; growth arrest and DNA-damage-inducible, beta; MYD118DKFZP566B133; Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118

Molecular Weight

Mass (kDA):
17.818 kDA

Genomic Context

Human
Location:	19p13.3
Sequence:	19; NC_000019.10 (2476127..2478259)

Diseases

• Growth Arrest
• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Inflammation
• Cell Transformation, Neoplastic
• Liver Carcinoma
• Liver Neoplasms
• Malignant Neoplasm Of Lung
• Leukemia
• Genotoxic Stress
• Malignant Neoplasm Of Breast
• Degenerative Polyarthritis

• Lung Neoplasms
• Growth Retardation
• Hypertrophy
• Hyperplasia
• Pancreatic Neoplasm
• Autoimmune Reaction
• Malignant Paraganglionic Neoplasm

Interacting Proteins

• MAP2K7
• MAP3K4

Pathways

• Cell Cycle
• Cell Death
• Cell Growth
• Dna Repair
• Cell Cycle Arrest
• Programmed Cell Death
• Cell Proliferation
• Demethylation
• Dna Demethylation
• Immune Response
• Methylation
• Cell Differentiation
• Dna Replication

• Pathogenesis
• Oncogenesis
• Regeneration
• Innate Immune Response
• Dna Methylation
• Neurogenesis
• Senescence

PTMs

• Phosphorylation
• Demethylation

• Methylation
• Cleavage

• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GADD45B

The Best Uses Of The GADD45B Marker From Boster Bio

Boster Bio has the GADD45B marker you need. They offer the ELISA Picoband and Picokine ELISA platforms, as well as Custom services. For more information, contact them today! Find out more about this powerful marker by reading the following. Boster Bio is here to help you make the most out your biomedical research.

Boster Bio's Picokine ELISA-platform

Boster also offers high-sensitivity ELISA kits. It also offers immunological reagents capable of detecting a variety antigens, proteins, and cytokines. Boster is a scientist who has more than 20-years of experience and is trusted by 10,000 scientists around the globe. Picokine ELISA kits are available for the GADD45B marker and contain enough reagents to perform 96 tests. These kits contain a comprehensive list with validated samples, which allow scientists to quickly perform accurate results.

Sanbio can provide more information about Boster Bio’s Picokine ELIISA Platform for the GADD45B Marker. It also offers custom service and BeNeLux shipping. Sanbio can be reached at (02) 661-8655. They will be happy and able to answer any questions that you may have and to help you get on the right track to accurate, high-quality ELISA testing results.

Picoband by Boster Bio

The Picoband GADD45B marker from Boster Bio is an anti-human antibody that reacts to the Human protein GADD45B. It can be stored at 4degC or -20degC for up 1 year. It is made up of synthetic peptide sequences as well as Trehalose. It is suitable for use in qPCR assays and immunohistochemistry.

Picoband GADD45B genes were first isolated from PTC cells. Their expression was determined by RTqPCR and TLDA custom analyses. GADD45B's expression was found significantly higher in PTC/RE patients than in FCO patients, compared to those who did not have it. This gene is also associated with shorter periods of disease-free survival.

Applications

Researchers have discovered that GADD45B plays an important role in radiation resistance. They exposed HONE1 cells to continuous radiation stimulation. The radioresistance of the cells was assessed using CCK-8, clone formation and transcriptome sequencing. The gRNAs used to target GADD45B were chemically modified (2'-OMe) to enhance knockdown and stability.

In the study, researchers selected two reference genes and 106 PTCs to analyze the expression of GADD45B. They found that GADD45B activated the G2/M cell-cycle cycle by activating it with ultraviolet radiation. Similarly, Inowa et al. determined that GADD45B inhibited the proliferation of tumor cells by acting on the CDK1/cyclin B1 gene.

GADD45B belongs to a class of growth arrest DNA-damage-inducible gene families. It plays a vital role in cell development, DNA repair, and apoptosis. The current study looked at the relationship between GADD45B and tumor progression in stage II colorectal Cancer. Tissue microarrays have been used to assess GADD45B expression. For stage II patients, survival analysis and stratification analyses also were performed.

The GADD45B gene is related to the NF-kB pathway. This pathway is important for cancer cell survival, invasion, metastasis, and metastasis. GADD45 family members are essential mediators of cell survival in tumor cells. This is why drug discovery is so important. The role of this gene in CRC carcinogenesis has been established, but it remains elusive. Its expression can also be linked to the expression other genes.

GADD45B is part of a group of genes that regulate cell differentiation and proliferation. They are highly expressed across a variety of mammalian tissues. Interestingly, they increase dramatically under stress and injury stimulation. The different roles of the proteins in GADD45's family are different in different cell types. GADD45B plays a role in the regulation of cell cycle, binding MEKK4/MEKK7, as well as inhibiting the JNK/p38 pathway.

In colorectal carcinoma tissues, the expression level of GADD45B genes has been investigated. The expression levels of GADD45B gene in colorectal cancer are reflected in the box plots. Tumors are colored red, while healthy tissue is green. Based on the major TNM staging of CRC patients, the highest value in box plots represents the highest expression level, while the lowest value corresponds to the lowest quartile.