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- Table of Contents
Facts about Gamma-aminobutyric acid receptor subunit gamma-2.
Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel.
Human | |
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Gene Name: | GABRG2 |
Uniprot: | P18507 |
Entrez: | 2566 |
Belongs to: |
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ligand-gated ion channel (TC 1.A.9) family |
CAE2; ECA2; GABA A R gamma 2; GABA(A) receptor subunit gamma-2; GABAAR gamma 2; GABAARg2; GABRG2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; gamma-aminobutyric acid receptor subunit gamma-2; GEFSP3
Mass (kDA):
54.162 kDA
Human | |
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Location: | 5q34 |
Sequence: | 5; NC_000005.10 (162067465..162155539) |
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cytoplasmic vesicle membrane.
PMID: 2538761 by Pritchett D.B., et al. Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology.
PMID: 11328646 by Jiang S., et al. Complete genomic sequence of 195 Kb of human DNA containing the gene GABRG2.