GABRA4 Antibodies

AND GABRA4 ELISA kits, GABRA4 Proteins

Many biological assays use antibodies to detect GABRA4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GABRA4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GABRA4 antibodies...

We validate the specificity of these antibodies to GABRA4 by testing them on tissues known to express GABRA4 positively and negatively. Browse below to find the GABRA4 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GABRA4 Infographic by Boster Bio

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GABRA4 Overview

Facts about Gamma-aminobutyric acid receptor subunit alpha-4.

GABRA4 3D structure. Source: alphafold

Gamma-aminobutyric acid receptor subunit alpha-4 (GABRA4)

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. .

Gene Information

Human
Gene Name:	GABRA4
Uniprot:	P48169
Entrez:	2557

Family

Belongs to:

ligand-gated ion channel (TC 1.A.9) family

Alternative Names

GABA A R alpha 4; GABA(A) receptor subunit alpha-4; GABAAR alpha 4; GABAARa4; GABRA4; gamma-aminobutyric acid (GABA) A receptor, alpha 4; gamma-aminobutyric acid receptor subunit alpha-4

Molecular Weight

Mass (kDA):
61.623 kDA

Genomic Context


Human

Location:	4p12
Sequence:	4; NC_000004.12 (46918900..46993581, complement)

Subcellular Localizations

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Diseases

Epilepsy
Anxiety Disorders
Autistic Disorder
Dysequilibrium Syndrome
Nicotine Dependence
Status Epilepticus
Schizophrenia
Tobacco Use Disorder
Epilepsy, Temporal Lobe
Schizoaffective Disorder
Premenstrual Dysphoric Disorder

Schizoaffective Disorder, Bipolar Type
Premenstrual Syndrome
Brain Injuries
Mental Disorders
Depressive Disorder
Amnesia

Pathways

Righting Reflex
Reflex
Proestrus
Pathogenesis
Transport
Cell Adhesion
Cell Proliferation
Sensory Processing
Synaptic Transmission
Neurogenesis
Neuron Development
Localization

Startle Response
Drug Resistance
Swimming
Diestrus
Cognition
Rna Interference
Taurine Transport

PTMs

Biotinylation

Research Areas

Neuronal Cell Markers
Neuroscience
Neurotransmission

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GABRA4

References

PMID: 8719416 by Yang W., et al. Cloning and characterization of the human GABAA receptor alpha 4 subunit: identification of a unique diazepam-insensitive binding site.

PMID: 7607683 by McLean P.J., et al. Mapping of the alpha 4 subunit gene (GABRA4) to human chromosome 4 defines an alpha 2-alpha 4-beta 1-gamma 1 gene cluster: further evidence that modern GABAA receptor gene clusters are derived from an ancestral cluster.