GABBR1 Antibodies

AND GABBR1 ELISA kits, GABBR1 Proteins

Many biological assays use antibodies to detect GABBR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GABBR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GABBR1 antibodies...

We validate the specificity of these antibodies to GABBR1 by testing them on tissues known to express GABBR1 positively and negatively. Browse below to find the GABBR1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GABBR1 Infographic by Boster Bio

All GABBR1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Phospho-GABAB R1 (Ser923) Antibody

1 Citations 5 Q&As

Mouse, Rat

$481
Cat # P07297
100 µl

Anti-GABA B Receptor 1/GABBR1 Antibody Picoband®

1 Q&As

Human, Mouse, Rat

$370
Cat # A07297-1
100 μg/vial

GABA-B Receptor Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$480
Cat # EKC1230
1 kit, containing one 96-well plate and all necessary reagents

Anti-GABAB R1 (I902) GABBR1 Antibody

Human, Mouse, Rat

IHC

$405
Cat # A07297-2
100ul

GABA B Receptor 1 (GABBR1) (NM_021904) Human Over-expression Lysate

Human

$960
Cat # LS002550
100 µg

GABBR1 Overview

Facts about Gamma-aminobutyric acid type B receptor subunit 1.

GABBR1 3D structure. Source: alphafold

Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)

Part of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054).
Within the heterodimeric GABA receptor, just GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688).

Ligand binding causes a conformation change that triggers signaling through guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10906333, PubMed:10773016, PubMed:10075644, PubMed:9872744, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644).

Gene Information

Human
Gene Name:	GABBR1
Uniprot:	Q9UBS5
Entrez:	2550

Family

Belongs to:

G-protein coupled receptor 3 family

Alternative Names

FLJ92613; GABA B R1; GABABR1; GABBR1; GABBR1-3; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid type B receptor subunit 1; Gb1; GPRC3A; GPRC3Asubunit 1c; hGB1a; seven transmembrane helix receptor

Molecular Weight

Mass (kDA):
108.32 kDA

Genomic Context


Human

Location:	6p22.1
Sequence:	6; NC_000006.12 (29602228..29633183, complement)

Tissue Specificity

Highly expressed in brain (PubMed:9844003, PubMed:9753614, PubMed:9872744). Weakly expressed in heart, small intestine and uterus. Isoform 1A: Mainly expressed in granular cell and molecular layer (PubMed:9844003). Isoform 1B: Mainly expressed in Purkinje cells (PubMed:9844003). Isoform 1E: Predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland (PubMed:10906333).

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane (PubMed:15617512).; [Isoform 1E]: Secreted.

Diseases

Epilepsy
Epilepsy, Temporal Lobe
Schizophrenia
Carcinoma
Cancer Of Nasopharynx
Malignant Neoplasms
Dysequilibrium Syndrome
Bipolar Disorder
Virus Diseases
Autistic Disorder
Nasopharyngeal Neoplasms
Neoplasms

Epstein-barr Virus Infections
Mental Disorders
Brain Diseases
Mood Disorders
Postmortem Changes
Absence Epilepsy
Autoimmunity

Interacting Proteins

GABBR2
GPR37
MAX
NCK1
NSF

Pathways

Synaptic Transmission
Pathogenesis
Localization
Reverse Transcription
Conditioned Taste Aversion
Aging
Cortisol Secretion
Viral Replication

Rna Interference
Secretion

PTMs

Disulfide bond

Glycoprotein

Phosphoprotein

Research Areas

GPCR
Neuronal Cell Markers
Neuroscience
Neurotransmission

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GABBR1

References

PMID: 9844003 by Kaupmann K., et al. Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels.

PMID: 9872316 by White J.H., et al. Heterodimerization is required for the formation of a functional GABA(B) receptor.

1 Publications of Boster GABBR1 Antibodies & ELISA Kits

PubMed ID: 10.1155/2021/5566078, The Herbal Constituents in An-Gong-Niu-Huang Wan (AGNH) Protect against Cinnabar...

*More publications can be found for each product on its corresponding product page