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, No Gclids
GAA Antibodies
AND GAA ELISA kits, GAA Proteins
Many biological assays use antibodies to detect GAA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GAA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GAA antibodies...
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GAA Infographic by Boster Bio
All GAA Products
Product
Figures
Specificity
Applications
Price
Human
IF, IHC, ICC, WB
$370
Cat # M01548
100 μg/vial
Cat # M01548
100 μg/vial
Human, Mouse, Rat
IP, IF, ICC, WB
$405
Cat # A01548-1
100ul
Cat # A01548-1
100ul
GAA Overview
Facts about Lysosomal alpha-glucosidase.
Lysosomal alpha-glucosidase (GAA)
Essential for the degradation of glycogen in lysosomes (PubMed:1856189, PubMed:7717400, PubMed:14695532, PubMed:18429042).
Has highest action on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans (PubMed:29061980)..
Gene Information
| Human | |
|---|---|
| Gene Name: | GAA |
| Uniprot: | P10253 |
| Entrez: | 2548 |
Family
| Belongs to: |
|---|
| glycosyl hydrolase 31 family |
Alternative Names
Acid alpha-Glucosidase; Acid Maltase; Aglucosidase alfa; EC 3.2.1.20; GAA; glucosidase, alpha; acid; LYAG; Lysosomal alphaGlucosidase; Lysosomal alpha-Glucosidase
Molecular Weight
Mass (kDA):
105.324 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.3 |
| Sequence: | 17; NC_000017.11 (80101535..80119881) |
Subcellular Localizations
Lysosome. Lysosome membrane.
Diseases
- Ataxia
- Friedreich Ataxia
- Glycogen Storage Disease Type Ii
- Glycogen Storage Disease
- Trinucleotide Repeat Expansion
- Storage Disease
- Cardiomyopathies
- Neurodegenerative Disorders
- Weakness
- Myopathy
- Hypertrophy
- Diabetes Mellitus
- Muscle Weakness
Pathways
- Pathogenesis
- Transport
- Translation
- Excretion
- Secretion
- Dna Replication
- Localization
- Methylation
- Autophagy
- Immune Response
- Glycosylation
- Hypersensitivity
- Oxidative Phosphorylation
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Acetylation
- Reduction
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GAA
bosterbio.com/bosterbio-gene-info-cards/GAA
References
PMID: 3049072 by Hoefsloot L.H., et al. Primary structure and processing of lysosomal alpha-glucosidase; homology with the intestinal sucrase-isomaltase complex.
PMID: 2268276 by Hoefsloot L.H., et al. Characterization of the human lysosomal alpha-glucosidase gene.