This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
FRZB Antibodies
AND FRZB ELISA kits, FRZB Proteins
Many biological assays use antibodies to detect FRZB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FRZB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FRZB antibodies...
Previous: CCN2
Next: CENPI
FRZB Infographic by Boster Bio
All FRZB Products
Product
Figures
Specificity
Applications
Price
FRZB Overview
Facts about Secreted frizzled-related protein 3.
Secreted frizzled-related protein 3 (FRZB)
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in particular cell types.
SFRP3/FRZB seems to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling.
Gene Information
| Human | |
|---|---|
| Gene Name: | FRZB |
| Uniprot: | Q92765 |
| Entrez: | 2487 |
Family
| Belongs to: |
|---|
| secreted frizzled-related protein (sFRP) family |
Alternative Names
FIZ; FREOS1; Frezzled; Fritz; Frizzled-related protein 1; frizzled-related protein; FRP; FRP-3; FRZB; Frzb1; FRZB-1; FRZB1sFRP-3; FRZB-PEN; FZRB; hFIZ; secreted frizzled-related protein 3; sFRP3; sFRP-3; SFRP3frezzled; SRFP3frizzled homolog-related
Molecular Weight
Mass (kDA):
36.254 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q32.1 |
| Sequence: | 2; NC_000002.12 (182833275..182866637, complement) |
Tissue Specificity
Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in early chondroblasts of the tarsal bones of the foot, the carpal bones of the hands and the epiphysis of long bones. Highly expressed in placenta and heart, followed by brain, skeletal muscle, kidney and pancreas. Weakly expressed in lung and liver.
Subcellular Localizations
Secreted.
Diseases
- Degenerative Polyarthritis
- Osteoarthritis Of Hip
- Malignant Neoplasms
- Neoplasms
- Osteoarthritis, Knee
- Generalized Osteoarthritis
- Osteoporosis
- Arthritis
- Cell Invasion
- Malignant Neoplasm Of Prostate
- Neoplasm Invasiveness
- Malignant Paraganglionic Neoplasm
Pathways
- Ossification
- Bone Development
- Gastrulation
- Cell Proliferation
- Pathogenesis
- Localization
- Chondrocyte Differentiation
- Endochondral Ossification
- Secretion
- Cell Division
- Cell Differentiation
- Convergent Extension
- Notochord Formation
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FRZB
bosterbio.com/bosterbio-gene-info-cards/FRZB
References
PMID: 8824257 by Hoang B., et al. Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis.
PMID: 9178261 by Mayr T., et al. Fritz: a secreted frizzled-related protein that inhibits Wnt activity.
1 Publications of Boster FRZB Antibodies & ELISA Kits
- PubMed ID: 10.1007/s10157-015-1167-2, miR-363 induces transdifferentiation of human kidney tubular cells to mesenchyma...
*More publications can be found for each product on its corresponding product page