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- Table of Contents
Facts about Leucine-rich repeat transmembrane protein FLRT2.
May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron advice via its interaction with UNC5D, and possibly also other UNC-5 household members.
Human | |
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Gene Name: | FLRT2 |
Uniprot: | O43155 |
Entrez: | 23768 |
Belongs to: |
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No superfamily |
Fibronectin Leucine Rich Transmembrane Protein 2; Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 2; FLRT2; KIAA0405; Leucine-Rich Repeat Transmembrane Protein FLRT2
Mass (kDA):
74.049 kDA
Human | |
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Location: | 14q31.3 |
Sequence: | 14; NC_000014.9 (85527372..85654428) |
Expressed in pancreas, skeletal muscle, brain, and heart.
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane. Cell junction, focal adhesion. Secreted, extracellular space, extracellular matrix. Microsome membrane. Secreted. Cell junction, synapse, synaptosome. Proteolytic cleavage gives rise to a shedded ectodomain.
PMID: 10644439 by Lacy S.E., et al. Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins.