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- Table of Contents
Facts about Fibroblast growth factor receptor 4.
Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades.
Human | |
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Gene Name: | FGFR4 |
Uniprot: | P22455 |
Entrez: | 2264 |
Belongs to: |
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protein kinase superfamily |
CD334 antigen; CD334; EC 2.7.10; EC 2.7.10.1; FGF R4; FGFR4; FGFR-4; fibroblast growth factor receptor 4; JTK2hydroxyaryl-protein kinase; MGC20292; protein-tyrosine kinase; TKF; tyrosine kinase related to fibroblast growth factor receptor; tyrosylprotein kinase
Mass (kDA):
87.954 kDA
Human | |
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Location: | 5q35.2 |
Sequence: | 5; NC_000005.10 (177086915..177098144) |
Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.
Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.; [Isoform 2]: Secreted.; [Isoform 3]: Cytoplasm.
PMID: 1709094 by Partanen J.M., et al. FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.
PMID: 7680645 by Ron D., et al. Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor.