This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about F-box only protein 5.
During G1 phase, plays a role as portion of APC-FZR1 complicated E3 ligase (PubMed:29875408). Then switches as an inhibitor of APC-FZR1 complicated during S and G2 resulting in cell- cycle commitment (PubMed:29875408).
Human | |
---|---|
Gene Name: | FBXO5 |
Uniprot: | Q9UKT4 |
Entrez: | 26271 |
Belongs to: |
---|
No superfamily |
EMI1Early mitotic inhibitor 1; F-box only protein 5; F-box protein 5; FBX5F-box protein Fbx5; Fbxo31
Mass (kDA):
50.146 kDA
Human | |
---|---|
Location: | 6q25.2 |
Sequence: | 6; NC_000006.12 (152970535..152983579, complement) |
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration (PubMed:11988738). In mitotic cells, localizes throughout the cell, particularly at the spindle (PubMed:15469984).
PMID: 10531035 by Cenciarelli C., et al. Identification of a family of human F-box proteins.
PMID: 11988738 by Hsu J.Y., et al. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1).