FZR1 Antibodies

AND FZR1 ELISA kits, FZR1 Proteins

Many biological assays use antibodies to detect FZR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FZR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FZR1 antibodies...

We validate the specificity of these antibodies to FZR1 by testing them on tissues known to express FZR1 positively and negatively. Browse below to find the FZR1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FZR1 Infographic by Boster Bio

All FZR1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A03219-1
100ul

Anti-FZR Antibody

Human

$299
Cat # M03219
50 µl

FZR1 Overview

Facts about Fizzy-related protein homolog.

FZR1 3D structure. Source: alphafold

Fizzy-related protein homolog (FZR1)

Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase.

The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle don't accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C.

Gene Information

Human
Gene Name:	FZR1
Uniprot:	Q9UM11
Entrez:	51343

Family

Belongs to:

WD repeat CDC20/Fizzy family

Alternative Names

CDC20C; CDH1; Cdh1/Hct1 homolog; CDH1CDC20-like 1b; fizzy/cell division cycle 20 related 1 (Drosophila); Fzr; FZR2; FZRCDC20-like protein 1; hCDH1; HCDHFYR; KIAA1242fizzy-related protein homolog

Molecular Weight

Mass (kDA):
55.179 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (3506263..3538334)

Tissue Specificity

Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas isoform 3 is expressed only at low levels in these tissues.

Subcellular Localizations

[Isoform 2]: Nucleus.; [Isoform 3]: Cytoplasm.

Diseases

Neoplasms
Carcinoma
Malignant Neoplasms
Cell Transformation, Neoplastic
Tissue Adhesions
Malignant Neoplasm Of Breast
Mammary Neoplasms
Endoreduplication
Genomic Instability
Neoplasm Metastasis
Melanoma
Aneuploidy

Infertility
Renal Cell Carcinoma
Malignant Paraganglionic Neoplasm
Neurodegenerative Disorders
Carcinogenesis
Alzheimer's Disease
Stomach Neoplasms

Interacting Proteins

CDC27
CLSPN
MAD2L2
MAK
RAD17

RRM2
SKP2
VHL

Pathways

Cell Cycle
Mitosis
Anaphase
Meiosis
Prophase
Meiosis I
Spindle Assembly
Cell Division
Cell Proliferation
Proteolysis
Spindle Assembly Checkpoint
Metaphase
Cell Differentiation

Dna Replication
Meiosis Ii
Localization
Exit From Mitosis
S Phase
Chromosome Segregation
G1 Phase

PTMs

Phosphorylation
Ubiquitination

Methylation
Farnesylation

Deacetylation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FZR1

References

PMID: 9811605 by Kramer E.R., et al. Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family.

PMID: 12797865 by Zhou Y., et al. Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1.