FRZB Antibodies

Secreted frizzled-related protein 3 (FRZB)

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in particular cell types.

SFRP3/FRZB seems to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling.

Gene Information

Human
Gene Name:	FRZB
Uniprot:	Q92765
Entrez:	2487

Family

Belongs to:
secreted frizzled-related protein (sFRP) family

Alternative Names

FIZ; FREOS1; Frezzled; Fritz; Frizzled-related protein 1; frizzled-related protein; FRP; FRP-3; FRZB; Frzb1; FRZB-1; FRZB1sFRP-3; FRZB-PEN; FZRB; hFIZ; secreted frizzled-related protein 3; sFRP3; sFRP-3; SFRP3frezzled; SRFP3frizzled homolog-related

Molecular Weight

Mass (kDA):
36.254 kDA

Genomic Context

Human
Location:	2q32.1
Sequence:	2; NC_000002.12 (182833275..182866637, complement)

Tissue Specificity

Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in early chondroblasts of the tarsal bones of the foot, the carpal bones of the hands and the epiphysis of long bones. Highly expressed in placenta and heart, followed by brain, skeletal muscle, kidney and pancreas. Weakly expressed in lung and liver.

Subcellular Localizations

Secreted.

Diseases

• Degenerative Polyarthritis
• Osteoarthritis Of Hip
• Malignant Neoplasms
• Neoplasms
• Osteoarthritis, Knee
• Generalized Osteoarthritis
• Osteoporosis
• Arthritis
• Cell Invasion
• Malignant Neoplasm Of Prostate
• Neoplasm Invasiveness
• Malignant Paraganglionic Neoplasm

• Fracture
• Malignant Neoplasm Of Stomach
• Osteophyte
• Stomach Neoplasms
• Sarcoma
• Hypertrophy
• Musculoskeletal Diseases

Pathways

• Ossification
• Bone Development
• Gastrulation
• Cell Proliferation
• Pathogenesis
• Localization
• Chondrocyte Differentiation
• Endochondral Ossification
• Secretion
• Cell Division
• Cell Differentiation
• Convergent Extension
• Notochord Formation

• Reverse Transcription
• Translation
• Cell Cycle
• Methylation
• Cell Adhesion
• Neural Tube Closure
• Spinal Cord Development

PTMs

• Phosphorylation

• Methylation

• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FRZB

Best Uses Of The FRZB Marker

Steven Boster’s Frizb marker is an excellent choice if your goal is to find a protein marker capable of working across multiple cultures. This protein is ideal for SDS/PAGE and has a 33-325 sequence domain. It can be stored at +2degC- +8degC up to one week or at -20degC- -80degC long-term storage. Avoid repeated freeze-thacility to keep it at its best. FRZB is applicable to scientists world-wide, regardless of their location.

FRZB Marker

The gene FRZB regulates osteoblast activity in many tissues. This gene has a cysteine-rich region that is identical to the WNT binding region. It is also homologous to tissue inhibitors metalloproteases. Studies have shown that this gene has polymorphisms that are associated with osteoarthritis. FRZB, which affects the thickness and integrity of cortical bone and cartilage, is thought to be an osteoblast regulator gene. This gene also suppresses WNT/b-catenin target genes.