Protein FRG1 Antibodies

AND FRG1 ELISA kits, Protein FRG1 Proteins

Many biological assays use antibodies to detect Protein FRG1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein FRG1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein FRG1 antibodies...

We validate the specificity of these antibodies to Protein FRG1 by testing them on tissues known to express FRG1 positively and negatively. Browse below to find the FRG1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FRG1 Infographic by Boster Bio

All FRG1 Products

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Specificity

Applications

Price

FRG1 (NM_004477) Human Over-expression Lysate

Human

$628
Cat # LS002483
100 µg

Anti-FRG1 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IF, ICC, WB

$370
Cat # M04940
100 µl/vial

FRG1 Overview

Facts about Protein FRG1.

FRG1 3D structure. Source: alphafold

Protein FRG1 (FRG1)

Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the gathering of rRNA into ribosomal subunits.

May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N- methyltransferase KMT5B.

Gene Information

Human
Gene Name:	FRG1
Uniprot:	Q14331
Entrez:	2483

Family

Belongs to:

FRG1 family

Alternative Names

facioscapulohumeral muscular dystrophy region gene-1; FSG1FRG1A; FSHD region gene 1 protein; FSHD region gene 1; protein FRG1

Molecular Weight

Mass (kDA):
29.172 kDA

Genomic Context


Human

Location:	4q35.2
Sequence:	4; NC_000004.12 (189940846..189963204)

Tissue Specificity

Expressed in adult muscle, lymphocytes, fetal brain, muscle, and placenta. Also expressed in the smooth muscle of arteries and veins, the sweat glands and the epidermis.

Subcellular Localizations

Nucleus, Cajal body. Nucleus, nucleolus. Cytoplasm. Cytoplasm, myofibril, sarcomere, Z line. Localization changes during myogenesis from mainly cytoplasmic in undifferentiated myoblasts, to strongly nucleolar in early myotubes and back to cytoplasmic 5 days post-differentiation (PubMed:20970242). Localized at the Z-line in the sarcomere of matured myotubes 8 days post-differentiation (PubMed:20970242).

Diseases

Muscular Dystrophy, Facioscapulohumeral
Dystrophy
Muscular Dystrophy
Neuromuscular Diseases
Myopathy
Weakness
Hereditary Diseases
Atrophy
Muscular Dystrophy, Animal
Facioscapulohumeral Muscular Dystrophy 1a
Malnutrition
Tumor Angiogenesis
Myotonic Dystrophy

Dysmyelopoietic Syndromes
Muscular Atrophy
Muscle Weakness
Childhood Soft Tissue Sarcoma
Oncogene Deregulation
Acquired Kyphosis
Sarcoma

Interacting Proteins

CWC22
EXOSC8
KRT40
LZTS2

Pathways

Localization
Pathogenesis
Transport
Methylation
Myoblast Proliferation
Myoblast Differentiation
Dna Methylation
Regeneration
Angiogenesis
Rna Interference
Gene Silencing
Muscle Contraction
Histone Modification

Biosynthetic Process
Response To Oxidative Stress
Muscle Attachment
Translation
Cell Cycle
Cell Differentiation
Interphase

PTMs

Phosphorylation
Acetylation

Methylation
Demethylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FRG1

References

PMID: 8733123 by van Deutekom J.C.T., et al. Identification of the first gene (FRG1) from the FSHD region on human chromosome 4q35.

PMID: 10512680 by van Geel M., et al. The FSHD region on human chromosome 4q35 contains potential coding regions among pseudogenes and a high density of repeat elements.