FPR2 Antibodies

AND FPR2 ELISA kits, FPR2 Proteins

Many biological assays use antibodies to detect FPR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FPR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FPR2 antibodies...

We validate the specificity of these antibodies to FPR2 by testing them on tissues known to express FPR2 positively and negatively. Browse below to find the FPR2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FPR2 Infographic by Boster Bio

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FPRL1 (FPR2) (NM_001462) Human Over-expression Lysate

Human

$628
Cat # LS002358
100 µg

FPR2 Overview

Facts about N-formyl peptide receptor 2.

FPR2 3D structure. Source: alphafold

N-formyl peptide receptor 2 (FPR2)

Low affinity receptor for N-formyl-methionyl peptides, which can be strong neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236).

This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339).

Gene Information

Human
Gene Name:	FPR2
Uniprot:	P25090
Entrez:	2358

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

ALXR; FMLP-R-I; FMLP-R-II; FMLPX; formyl peptide receptor 2; Formyl peptide receptor-like 1RFP; FPR2; FPR2A; FPRH1FMLP-related receptor I; FPRL1; FPRL1LXA4 receptor; HM63; HM63FPRH2; lipoxin A4 receptor (formyl peptide receptor related); Lipoxin A4 receptor; LXA4 Receptor; LXA4RFMLP-R-I; N-formyl peptide receptor 2; RFP

Molecular Weight

Mass (kDA):
38.964 kDA

Genomic Context


Human

Location:	19q13.41
Sequence:	19; NC_000019.10 (51752026..51770531)

Tissue Specificity

Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized.

Diseases

Inflammation
Pertussis
Alzheimer's Disease
Inflammatory Response
Arthritis
Tissue Adhesions
Rheumatoid Arthritis
Neurodegenerative Disorders
Hiv Infections
Asthma
Immunologic Deficiency Syndromes
Neoplasms

Infective Disorder
Atherosclerosis
Malignant Neoplasms
Innate Immune Response
Bacterial Infections
Chronic Inflammation
Inflammatory Disorder

Pathways

Chemotaxis
Secretion
Inflammatory Response
Pathogenesis
Cell Migration
Cell Proliferation
Immune Response
Phagocytosis
Neutrophil Chemotaxis
Virulence
Cell Adhesion
Cell Activation
Neutrophil Activation

Leukocyte Migration
Wound Healing
Localization
Cell Death
Exocytosis
Innate Immune Response
Endocytosis

PTMs

Phosphorylation
Formylation
Cleavage
Acetylation

Dephosphorylation
Biotinylation
Reduction
Glycosylation

Methylation

Research Areas

Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FPR2

References

PMID: 1612600 by Bao L., et al. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.

PMID: 1511907 by Perez H.D., et al. Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils.