Forkhead box protein E3 (FOXE3)

Transcription factor that regulates lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:22527307, PubMed:25504734). During lens development, controls the ratio of the lens fiber cells into the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity).

Controls lens vesicle closed and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is a must for the development of the anterior segment of the eye (PubMed:27218149).