Forkhead box protein C1 Antibodies

AND FOXC1 ELISA kits, Forkhead box protein C1 Proteins

Many biological assays use antibodies to detect Forkhead box protein C1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Forkhead box protein C1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Forkhead box protein C1 antibodies...

We validate the specificity of these antibodies to Forkhead box protein C1 by testing them on tissues known to express FOXC1 positively and negatively. Browse below to find the FOXC1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FOXC1 Infographic by Boster Bio

All FOXC1 Products

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Product

Figures

Specificity

Applications

Price

Anti-FoxC1/2 Antibody

4 Q&As

Human, Mouse, Rat

$399
Cat # A00962-1
100μl

Anti-FOXC1 Antibody Picoband®

1 Q&As

Human

ELISA, WB

$370
Cat # A00962-2
100 μg/vial

Anti-FoxC1/2 (K138) Antibody

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A00962
100ul

FOXC1 (NM_001453) Human Over-expression Lysate

Human

$960
Cat # LS002296
100 µg

FOXC1 Overview

Facts about Forkhead box protein C1.

FOXC1 3D structure. Source: alphafold

Forkhead box protein C1 (FOXC1)

DNA-binding transcriptional factor that plays a part in a broad selection of developmental and cellular processes like eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:15299087, PubMed:15684392, PubMed:16492674, PubMed:27907090, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:16449236, PubMed:17210863, PubMed:19793056, PubMed:19279310, PubMed:25786029, PubMed:27804176). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:7957066, PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176).

Upon DNA-binding, promotes DNA bending (PubMed:7957066, PubMed:14506133). Stimulates Indian hedgehog (Ihh)- induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity).

Gene Information

Human
Gene Name:	FOXC1
Uniprot:	Q12948
Entrez:	2296

Family

Belongs to:

No superfamily

Alternative Names

ARA; FKHL7; FKHL7RIEG3; forkhead box C1; forkhead box protein C1; forkhead, drosophila, homolog-like 7; forkhead/winged helix-like transcription factor 7; forkhead-related activator 3; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FoxC1; FREAC3; FREAC-3; FREAC3IRID1; IGDA; IHG1; IRID1; myeloid factor-delta; RIEG3

Molecular Weight

Mass (kDA):
56.789 kDA

Genomic Context


Human

Location:	6p25.3
Sequence:	6; NC_000006.12 (1609915..1613897)

Tissue Specificity

Expressed in keratinocytes of epidermis and hair follicle (PubMed:27907090). Expressed strongly in microvascular invasion (MVI) formation, basal-like breast cancer (BLBC) and hepatocellular tumors (PubMed:20406990, PubMed:22991501). Expressed in breast cancers (at protein level) (PubMed:26565916). Expressed in hematopoietic cells (PubMed:8499623).

Subcellular Localizations

Nucleus. Colocalizes with PITX2 isoform 3 in the nucleus at subnuclear chromatine regions (PubMed:16449236). Colocalizes with CBX5 to a heterochromatin-rich region of the nucleus (PubMed:15684392). Colocalizes with GLI2 in the nucleus (By similarity).