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Folate receptor alpha Antibodies
AND FOLR1 ELISA kits, Folate receptor alpha Proteins
Many biological assays use antibodies to detect Folate receptor alpha, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Folate receptor alpha in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Folate receptor alpha antibodies...
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FOLR1 Infographic by Boster Bio
All FOLR1 Products
Product
Figures
Specificity
Applications
Price
Human FOLR1/Alpha Fr ELISA Kit PicoKine®
1 Citations 7 Q&As
Human
ELISA
$499
Cat # EK1242
96 wells/kit, with removable strips.
Cat # EK1242
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # EK1243
96 wells/kit, with removable strips.
Cat # EK1243
96 wells/kit, with removable strips.
Human
$628
Cat # LS002348
100 µg
Cat # LS002348
100 µg
FOLR1 Overview
Facts about Folate receptor alpha.
Folate receptor alpha (FOLR1)
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.
Exposure to slightly acidic pH after receptor endocytosis activates a conformation change that dramatically reduces its affinity for folates and mediates their discharge. Required for normal embryonic development and normal cell proliferation.
Gene Information
| Human | |
|---|---|
| Gene Name: | FOLR1 |
| Uniprot: | P15328 |
| Entrez: | 2348 |
Family
| Belongs to: |
|---|
| folate receptor family |
Alternative Names
Adult folate-binding protein; FBP; folate binding protein; folate receptor 1 (adult); Folate receptor 1; folate receptor alpha; Folate receptor, adult; Folbp1; FOLR; FOLR1; FR-alpha; KB cells FBP; MOv18; Ovarian tumor-associated antigen MOv18
Molecular Weight
Mass (kDA):
29.819 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.4 |
| Sequence: | 11; NC_000011.10 (72189709..72196323) |
Tissue Specificity
Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.
Subcellular Localizations
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane. Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- 5,10-methylenetetrahydrofolate Reductase Deficiency
- Folic Acid Deficiency
- Ovarian Neoplasm
- Congenital Abnormality
- Lung Neoplasms
- Adenocarcinoma
- Malignant Neoplasm Of Lung
- Malignant Neoplasm Of Ovary
- Cystadenocarcinoma, Serous
- Non-small Cell Lung Carcinoma
Pathways
- Transport
- Methylation
- Pathogenesis
- Cell Cycle
- Neural Tube Closure
- Brain Development
- Myelination
- Translation
- Cell Proliferation
- Dna Methylation
- Localization
- Tube Closure
- Cell Migration
PTMs
- Methylation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FOLR1
bosterbio.com/bosterbio-gene-info-cards/FOLR1
References
PMID: 2768245 by Elwood P.C.; Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells.
PMID: 2527252 by Lacey S.W., et al. Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol.
2 Publications of Boster Folate receptor alpha Antibodies & ELISA Kits
- PubMed ID: 10.1186/s12903-019-0909-z, Folate-receptor 1 level in periodontal disease: a pilot study
- PubMed ID: 24845203, Powerful inner/outer controlled multi-target magnetic nanoparticle drug carrier ...
*More publications can be found for each product on its corresponding product page