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FOLH1 Antibodies
AND FOLH1 ELISA kits, FOLH1 Proteins
Many biological assays use antibodies to detect FOLH1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FOLH1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FOLH1 antibodies...
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FOLH1 Infographic by Boster Bio
All FOLH1 Products
Product
Figures
Specificity
Applications
Price
Human
IHC, WB
$431
Cat # M02846-1
100uL
Cat # M02846-1
100uL
Anti-PSMA Purified FOLH1 Monoclonal Antibody
1 Citations
Human, Mouse, Pig, Rat
IHC-P, ICC, WB
$337
Cat # M02846-2
0.1 mg
Cat # M02846-2
0.1 mg
Human, Mouse
Flow Cytometry, IF, IHC, WB
$523
Cat # M02846-3
100 µl
Cat # M02846-3
100 µl
FOLH1 Overview
Facts about Glutamate carboxypeptidase 2.
Glutamate carboxypeptidase 2 (FOLH1)
Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides.
In the intestine, required for the uptake of folate. In the mind, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate.
Gene Information
| Human | |
|---|---|
| Gene Name: | FOLH1 |
| Uniprot: | Q04609 |
| Entrez: | 2346 |
Family
| Belongs to: |
|---|
| peptidase M28 family |
Alternative Names
Cell growth-inhibiting gene 27 protein; cell growth-inhibiting protein 27; EC 3.4.17.21; FGCP; folate hydrolase (prostate-specific membrane antigen) 1; Folate hydrolase 1; FOLH1; FOLHNAALADase I; Folylpoly-gamma-glutamate carboxypeptidase; GCP2; GCPII; GCPIImGCP; glutamate carboxylase II; glutamate carboxypeptidase 2; Glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; mopsm; NAALAD1; NAALAD1N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; NAALAdase; N-acetylated alpha-linked acidic dipeptidase 1; prostate specific membrane antigen variant F; Prostate-specific membr
Molecular Weight
Mass (kDA):
84.331 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p11.12 |
| Sequence: | 11; NC_000011.10 (49145092..49208642, complement) |
Tissue Specificity
Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-3 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer.
Subcellular Localizations
Cell membrane; Single-pass type II membrane protein.; [Isoform PSMA']: Cytoplasm.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Prostate
- 5,10-methylenetetrahydrofolate Reductase Deficiency
- Prostatic Neoplasms
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Cholangiocarcinoma
- Neoplasm Metastasis
- Brain Ischemia
- Hyperhomocysteinemia
- Adenocarcinoma
- Cerebrovascular Accident
- Colorectal Cancer
Pathways
- Methylation
- Dna Methylation
- Cell Proliferation
- Locomotion
- Chromosome Breakage
- Regulation Of Gene Expression
- Mating
- Cognition
PTMs
- Acetylation
- Methylation
Research Areas
- Cancer
- Prostate Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FOLH1
bosterbio.com/bosterbio-gene-info-cards/FOLH1
References
PMID: 8417812 by Israeli R.S., et al. Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen.
PMID: 7882349 by Su S.L., et al. Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression.
1 Publications of Boster FOLH1 Antibodies & ELISA Kits
- PubMed ID: 31105564, Ability to Suppress TGF-β-Activated Myofibroblast Differentiation Distinguishes...
*More publications can be found for each product on its corresponding product page