FNIP2 Antibodies

AND FNIP2 ELISA kits, FNIP2 Proteins

Many biological assays use antibodies to detect FNIP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FNIP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FNIP2 antibodies...

We validate the specificity of these antibodies to FNIP2 by testing them on tissues known to express FNIP2 positively and negatively. Browse below to find the FNIP2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FNIP2 Infographic by Boster Bio

All FNIP2 Products

Product

Figures

Specificity

Applications

Price

Anti-FNIP2 Antibody

Human, Mouse, Rat

ELISA, IHC-P, WB

$449
Cat # A08631
0.1 mg

FNIP2 (NM_020840) Human Recombinant Protein

$1249
Cat # PROTQ9P278
20 µg

FNIP2 (NM_020840) Human Over-expression Lysate

Human

$960
Cat # LS057600
100 µg

FNIP2 Overview

Facts about Folliculin-interacting protein 2.

FNIP2 3D structure. Source: alphafold

Folliculin-interacting protein 2 (FNIP2)

Acts as a co-chaperone of HSP90AA1.
Inhibits the ATPase activity of HSP90AA1 leading to decrease in its chaperone action.

Facilitates the binding of client protein FLCN to HSP90AA1 (PubMed:27353360). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine- mispaired lesions (By similarity).

Gene Information

Human
Gene Name:	FNIP2
Uniprot:	Q9P278
Entrez:	57600

Family

Belongs to:

FNIP family

Alternative Names

FNIP1-like protein; FNIPL; folliculin interacting protein 2

Molecular Weight

Mass (kDA):
122.115 kDA

Genomic Context


Human

Location:	4q32.1
Sequence:	4; NC_000004.12 (158769026..158908050)

Tissue Specificity

Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver, heart, placenta and pancreas. Moderately expressed in the lung, small intestine, kidney and brain. Lower levels detected in renal cell carcinoma than in normal kidney tissue (PubMed:18403135). Higher levels detected in oncocytoma tumors than in normal kidney. Higher levels detected in renal cell carcinoma tumors than in normal kidney tissue (PubMed:27353360).

Subcellular Localizations

Cytoplasm. Colocalizes with FLCN in the cytoplasm.

Diseases

Neoplasms
Kidney Neoplasm
Renal Cell Carcinoma
Sclerosis
Primary Lateral Sclerosis
Dementia
Amyotrophic Lateral Sclerosis
Carcinoma
Conventional (clear Cell) Renal Cell Carcinoma

Malignant Neoplasms
Oncocytic Neoplasm
Multiple Fibrofolliculomas

Pathways

Mismatch Repair
Dna Replication
Induction Of Apoptosis
Cell Death
Pathogenesis
Chromosome Segregation

Autophagy

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FNIP2

References

PMID: 18403135 by Hasumi H., et al. Identification and characterization of a novel folliculin-interacting protein FNIP2.

PMID: 18663353 by Takagi Y., et al. Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnip1-like (FnipL/Fnip2) protein.