FLVCR1 Antibodies

AND FLVCR1 ELISA kits, FLVCR1 Proteins

Many biological assays use antibodies to detect FLVCR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FLVCR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FLVCR1 antibodies...

We validate the specificity of these antibodies to FLVCR1 by testing them on tissues known to express FLVCR1 positively and negatively. Browse below to find the FLVCR1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FLVCR1 Infographic by Boster Bio

All FLVCR1 Products

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Product

Figures

Specificity

Applications

Price

Anti-FLVC1 FLVCR1 Antibody

Human

ELISA, WB

$380
Cat # A05270
100ul

FLVCR (FLVCR1) (NM_014053) Human Over-expression Lysate

Human

$628
Cat # LS028982
100 µg

FLVCR1 Overview

Facts about Feline leukemia virus subgroup C receptor-related protein 1.

FLVCR1 3D structure. Source: alphafold

Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1)

Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate goods in the heme biosynthetic pathway.

Doesn't export bilirubin. Heme export depends upon the presence of HPX and is needed to maintain free heme balance, protecting cells from heme toxicity.

Gene Information

Human
Gene Name:	FLVCR1
Uniprot:	Q9Y5Y0
Entrez:	28982

Family

Belongs to:

major facilitator superfamily

Alternative Names

ataxia, posterior column 1, with retinitis pigmentosa; AXPC1; feline leukemia virus subgroup C cellular receptor 1; Feline leukemia virus subgroup C receptor; feline leukemia virus subgroup C receptor-related protein 1; FLVCRFLJ33420; hFLVCR; MFSD7B; PCA; PCARP

Molecular Weight

Mass (kDA):
59.863 kDA

Genomic Context


Human

Location:	1q32.3
Sequence:	1; NC_000001.11 (212858275..212899363)

Tissue Specificity

Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney.

Subcellular Localizations

[Isoform 1]: Cell membrane; Multi-pass membrane protein.; [Isoform 2]: Mitochondrion membrane; Multi-pass membrane protein.

Diseases

Leukemia, Feline
Leukemia
Anemia
Anemia, Diamond-blackfan
Ataxia
Biemond Ataxia
Retinitis Pigmentosa
Congenital Abnormality
Neurodegenerative Disorders
Pure Red-cell Aplasia
Malignant Neoplasms

Hemorrhage
Hemochromatosis
Iron Overload
Virus Diseases
Vascular Diseases
Aplasia, Nos

Pathways

Transport
Heme Export
Localization
Pathogenesis
Ribosome Biogenesis
Heme Transport
Regulation Of Growth
Cell Development
Glycosylation
Translation

Cell Differentiation
Cell Growth
Oxygen Transport
Proprioception
Rrna Processing

PTMs

Glycoprotein

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FLVCR1

References

PMID: 10400745 by Tailor C.S., et al. A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily.

PMID: 11943475 by Lipovich L., et al. Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus.