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FLT1 Antibodies
AND FLT1 ELISA kits, FLT1 Proteins
Many biological assays use antibodies to detect FLT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FLT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FLT1 antibodies...
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FLT1 Infographic by Boster Bio
All FLT1 Products
Product
Figures
Specificity
Applications
Price
Human VEGFR1/sFLT1 ELISA Kit PicoKine®
14 Citations 15 Q&As
Human
ELISA
$399
Cat # EK0543
96 wells/kit, with removable strips.
Cat # EK0543
96 wells/kit, with removable strips.
Anti-VEGF Receptor 1/FLT1 Antibody Picoband®
2 Citations 6 Q&As
Human
WB
$370
Cat # PA1399
100 μg/vial
Cat # PA1399
100 μg/vial
Anti-VEGF Receptor 1/FLT1 Antibody Picoband®
2 Citations
Mouse, Rat
WB
$370
Cat # PA1966-1
100 μg/vial
Cat # PA1966-1
100 μg/vial
Mouse FLT1/VEGFR1 ELISA Kit PicoKine®
1 Citations 11 Q&As
Mouse
ELISA
$499
Cat # EK0589
96 wells/kit, with removable strips.
Cat # EK0589
96 wells/kit, with removable strips.
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00534
100 μl
Cat # M00534
100 μl
Anti-VEGF Receptor 1/FLT1 Antibody Picoband®
3 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00534
100 μg/vial
Cat # A00534
100 μg/vial
Anti-VEGF Receptor 1/FLT1 Antibody Picoband®
2 Citations
Human, Mouse, Rat
WB
$370
Cat # A00534-1
100 μg/vial
Cat # A00534-1
100 μg/vial
Human
$250
Cat # PROTP17948
2ug, 10ug, 100ug
Cat # PROTP17948
2ug, 10ug, 100ug
Mouse
$250
Cat # PROTP35969
2ug, 10ug, 1mg
Cat # PROTP35969
2ug, 10ug, 1mg
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$405
Cat # A00534-3
100ul
Cat # A00534-3
100ul
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00534Y1333-1
100ul
Cat # A00534Y1333-1
100ul
FLT1 Overview
Facts about Vascular endothelial growth factor receptor 1.
Vascular endothelial growth factor receptor 1 (FLT1)
Tyrosine-protein kinase that functions as a cell-surface receptor for VEGFA, VEGFB and PGF, plays a vital role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play a vital function as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells.
Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific.
Gene Information
| Human | |
|---|---|
| Gene Name: | FLT1 |
| Uniprot: | P17948 |
| Entrez: | 2321 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.10; EC 2.7.10.1; FLT; FLT1; Flt-1; Fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascularpermeability factor receptor); FRT; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor 1; Vascular permeability factor receptor; VEGF R1; VEGFR1; VEGFR-1
Molecular Weight
Mass (kDA):
150.769 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q12.3 |
| Sequence: | 13; NC_000013.11 (28300346..28495128, complement) |
Tissue Specificity
Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC).
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Endosome. Autophosphorylation promotes ubiquitination and endocytosis.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Cytoplasm.; [Isoform 6]: Cytoplasm.; [Isoform 7]: Cytoplasm.
Diseases
- Tumor Angiogenesis
- Pre-eclampsia
- Neoplasms
- Pathologic Neovascularization
- Malignant Neoplasms
- Hypoxia
- Hypertensive Disease
- Proteinuria Of Undiagnosed Cause
- Neoplasm Metastasis
- Carcinoma
- Cell Invasion
- Inflammation
Interacting Proteins
- CBL
- CRKL
- CTNNB1
- HCK
- HSPG2
- PGF
- PIK3R1
- PLCG1
- PTK2
- PTPN11
Pathways
- Angiogenesis
- Pathogenesis
- Cell Proliferation
- Secretion
- Endothelial Cell Proliferation
- Localization
- Tube Formation
- Cell Growth
- Cell Migration
- Chemotaxis
- Regeneration
- Wound Healing
- Cell Adhesion
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Glycosylation
- Nitration
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FLT1
bosterbio.com/bosterbio-gene-info-cards/FLT1
References
PMID: 2158038 by Shibuya M., et al. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.
PMID: 8248162 by Kendall R.L., et al. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.
18 Publications of Boster FLT1 Antibodies & ELISA Kits
- PubMed ID: 10.5606/ArchRheumatol.2019.7265, Serum Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor ...
- PubMed ID: 10.5021/ad.2016.28.1.30, Genetic Risk Factors for Psoriasis in Turkish Population: -1540 C/A, -1512 Ins18...
- PubMed ID: 10.3109/10641955.2015.1122035, Attenuation of hyperglycemia-induced apoptotic signaling and anti-angiogenic mil...
- PubMed ID: 10.1111/j.1745-7270.2007.00310.x, Soluble Fms‐like Tyrosine Kinase‐1 Expression Inhibits the Growth of Multipl...
- PubMed ID: 10.1111/hdi.12903, Soluble vascular endothelial growth factor receptor‐1 as a novel marker of art...
- PubMed ID: 10.1016/j.jvs.2010.08.020, The impact of vascular endothelial growth factor-transfected human endothelial c...
- PubMed ID: 10.1016/j.jconrel.2020.01.026, Ligand-installed anti-VEGF genomic nanocarriers for effective gene therapy of pr...
- PubMed ID: 10.1016/j.jaad.2019.03.055, Vascular endothelial growth factor gene polymorphisms in patients with rosacea: ...
- PubMed ID: 10.1016/j.biopha.2018.06.032, Protective effect of human umbilical cord mesenchymal stem cell exosomes on pres...
- PubMed ID: 10.1007/s11596-011-0682-y, Upregulation of sFlt-1 by trophoblasts induces the barrier dysfunction of glomer...
- PubMed ID: 10.1007/s11596-011-0143-7, Effects of maternal serum on permeability of glomerular endothelial cell membran...
- PubMed ID: -, Liu M,Wang RB,Xing JH,Tang YX.Nested Case–Control Study of Corin Combined with...
- PubMed ID: 33155365, Eroglu E, Kocyigit I, Kahriman G, Karakukcu C, Tuncay A, Zararsiz GE, Eren D, Ka...
- PubMed ID: 27216943, A novel polysaccharide from Sargassum integerrimum induces apoptosis in A549 cel...
- PubMed ID: 26848216, Genetic Risk Factors for Psoriasis in Turkish Population: -1540 C/A, -1512 Ins18...
- PubMed ID: 17622469, Liu J, Li J, Su C, Huang B, Luo S. Acta Biochim Biophys Sin (Shanghai). 2007 Jul...
- PubMed ID: 23868816, Bakir M, Bakir S, Sari I, Celik Vk, Gozel Mg, Engin A. J Med Virol. 2013 Oct;85(...
- PubMed ID: 23671638, Wu Y, You H, Ma P, Li L, Yuan Y, Li J, Ye X, Liu X, Yao H, Chen R, Lai K, Yang X...
*More publications can be found for each product on its corresponding product page