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, No Gclids
Figla Antibodies
AND Figla ELISA kits, Figla Proteins
Many biological assays use antibodies to detect Figla, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Figla in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Figla antibodies...
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Figla Overview
Facts about Factor in the germline alpha.
Factor in the germline alpha (Figla)
Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those who initiate folliculogenesis and the ones that encode the zona pellucida (ZP1, ZP2 and ZP3) necessary for fertilization and early embryonic survival.
Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it might regulate additional pathways that are vital for normal ovarian development.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Figla |
| Uniprot: | O55208 |
| Entrez: | 26910 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BHLHC8; Class C basic helix-loop-helix protein 8; factor in the germline alpha; FIGALPHA; folliculogenesis specific basic helix-loop-helix; Folliculogenesis-specific basic helix-loop-helix protein; POF6; Transcription factor FIGa
Molecular Weight
Mass (kDA):
21.529 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 6|6 C3 |
| Sequence: | 6; |
Tissue Specificity
Expressed only in the oocytes within the ovary and at lower level in the testis. Found in the resting oocytes of the primordial follicle cells, at the periphery of the ovary and in the hilar region. Also detected in growing oocytes, but at lower levels.
Diseases
- Infertility
- Premature Menopause
- Ovarian Failure, Premature
- Sterility
- Turner Syndrome
- Tissue Adhesions
- Lymphohistiocytosis, Hemophagocytic
- Female Infertility
- Amenorrhea
- Polyploidy
Pathways
- Oogenesis
- Fertilization
- Spermatogenesis
- Oocyte Development
- Sex Differentiation
- Localization
- Sex Determination
- Cell Differentiation
- Meiosis
- Cell Proliferation
- Oocyte Growth
- Ovulation
- Oocyte Maturation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Figla
bosterbio.com/bosterbio-gene-info-cards/Figla
References
PMID: 9362457 by Liang L.-F., et al. FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes.
PMID: 11023867 by Soyal S.M., et al. FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation.