FIG4 Antibodies

AND FIG4 ELISA kits, FIG4 Proteins

Many biological assays use antibodies to detect FIG4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FIG4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FIG4 antibodies...

We validate the specificity of these antibodies to FIG4 by testing them on tissues known to express FIG4 positively and negatively. Browse below to find the FIG4 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FIG4 Infographic by Boster Bio

All FIG4 Products

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Applications

Price

Anti-FIG4 Antibody

13 Q&As

Human, Mouse

$399
Cat # A04403
100μl

FIG4 (NM_014845) Human Recombinant Protein

$813
Cat # PROTQ92562
20 µg

FIG4 (NM_014845) Human Over-expression Lysate

Human

$628
Cat # LS009896
100 µg

FIG4 Overview

Facts about Polyphosphoinositide phosphatase.

FIG4 3D structure. Source: alphafold

Polyphosphoinositide phosphatase (FIG4)

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all 3 D5-phosphorylated polyphosphoinositide substrates in the purchase PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3.

Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. .

Gene Information

Human
Gene Name:	FIG4
Uniprot:	Q92562
Entrez:	9896

Family

Belongs to:

No superfamily

Alternative Names

ALS11polyphosphoinositide phosphatase; CMT4J; dJ249I4.1; EC 3.1.3; EC 3.1.3.-; EC 3.1.3.36; FIG4 homolog (S. cerevisiae); FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae); hSac3; KIAA0274FIG4 homolog, SAC domain containing lipid phosphatase; Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; Sac domain-containing inositol phosphatase 3; SAC domain-containing protein 3; SAC3FIG4 homolog, SAC1 domain containing lipid phosphatase

Molecular Weight

Mass (kDA):
103.635 kDA

Genomic Context


Human

Location:	6q21
Sequence:	6; NC_000006.12 (109691296..109825431)

Subcellular Localizations

Endosome membrane. Localization requires VAC14 and PIKFYVE.

Diseases

Charcot-marie-tooth Disease
Nerve Degeneration
Sclerosis
Primary Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Neurodegenerative Disorders
Gliosis
Peripheral Neuropathy
Motor Neuron Disease
Nervousness
Feline Urological Syndrome
Malignant Neoplasms

Neoplasms
Abnormal Degeneration
Hypopigmentation Disorder
Muscle Weakness
Weakness
Leukemia

Interacting Proteins

VAC14

Pathways

Transport
Autophagy
Cell Death
Pathogenesis
Myelination
Cell Proliferation
Endocytosis
Cell Migration
Pigmentation
Mitochondrial Fusion
Glucose Homeostasis
Mitochondrial Transport
Cell Cycle

Membrane Fission
Mating
Cell Morphogenesis
Exocytosis
Endosomal Transport
Ion Transport
Membrane Fusion

PTMs

Phosphorylation

Dephosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FIG4

References

PMID: 17556371 by Sbrissa D., et al. Core protein machinery for mammalian phosphatidylinositol 3,5- bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex.

PMID: 18950639 by Sbrissa D., et al. ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality.